Structural diversity and biological activities of caged Garcinia xanthones: recent updates
https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0001
Announcing a new review article publication for Acta Materia Medica journal. Caged xanthones are a class of natural compounds with approximately 200 members that are commonly isolated from the Garcinia genus in the Clusiaceae (formerly Guttiferae) family. They are often characterized by a notable 4-oxatricyclo[ 4.3.1.03,7]dec-2-one (caged) architecture with a common xanthone backbone. Because most caged xanthones have potent anticancer properties, they have become a target of interest in natural product chemistry. The unique chemical architectures and increasingly identified biological importance of these compounds have stimulated many studies and intense interest in their isolation, biological evaluation and mechanistic studies.
The authors of this article summarize recent progress and development in the chemistry and biological activity of caged Garcinia xanthones and of several compounds of non-Garcinia origin, from the years 2008 to 2021, providing an in-depth discussion of their structural diversity and medicinal potential. A preliminary discussion on structure-activity relationships is also provided.
Article Reference: Yee Lin Phang, Changwu Zheng and Hongxi Xu. Structural diversity and biological activities of caged Garcinia xanthones: recent updates. Acta Materia Medica. Vol. 1(1):72-95. DOI: 10.15212/AMM-2022-0001
Keywords: caged xanthone, gambogenic acid, isomorellin, neobractatin, anticancer, structure-activity relationship
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