News Release

Younger patients seeking knee replacement have similar arthritis severity, but more risk factors for surgical complications than older patients

Peer-Reviewed Publication

Wolters Kluwer Health

March 1, 2022 – Compared to older patients being evaluated for total knee arthroplasty (TKA), younger patients – under age 60 – have similar pain, disability, and willingness to undergo surgery, reports a study in The Journal of Bone & Joint SurgeryThe journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

However, because patients under 60 also have higher rates of potential risk factors for complications, orthopaedic surgeons are somewhat less likely to recommend TKA for this younger group, suggests the new research by Gillian A. Hawker, MD, MSc, of University of Toronto and colleagues. "Orthopaedic surgeons have to balance the patient's clinical need and willingness with the risk for complications and revision," Dr. Hawker comments. "When they factored all these things in together, they were just as likely to offer surgery to younger versus older people."

Call to incorporate appropriateness criteria into TKA decision-making

How do patient age and age-related characteristics affect recommendations for TKA? The researchers analyzed 2,037 patients with knee osteoarthritis (OA) examined for possible TKA at two arthroplasty centers from 2014 to 2016. Patients were evaluated on factors related to the appropriateness of TKA, including:

  • Need for TKA, based on knee symptoms and prior treatment
  • Readiness/willingness to undergo TKA
  • Health status, including risk factors for complications following TKA
  • Expectations of the results of TKA

About one-fourth of patients were less than 60 years old: 22.7% were aged 50 to 59 years and 3.3% were younger than 50 years. The younger patients had more severe pain and worse physical function compared with patients 60 years or older, and were more likely to rate their knee symptoms as "unacceptable." In all age groups, more than 92% of patients said they were "definitely willing" to undergo TKA.

Expected outcomes of TKA also differed by age. Patients under 60 were more likely to say that improved ability to exercise and participate in sports was a "very important" outcome of TKA. In contrast, older patients were more likely to cite less-demanding outcomes, such as going up and down stairs and being able to straighten the leg.

Patients in the younger age groups had higher rates of severe obesity and smoking. Obesity is a key risk factor for osteoarthritis, while smoking increases the risk of complications following TKA surgery.

After evaluation, orthopaedic surgeons recommended TKA for 73.6% of patients overall. That figure increased from 52.2%for patients under 50 years, to 71.0 % for those 50 to 59 years old and 75.4% for those 60 years or older.

However, the effects of age were lessened after adjustment for other factors. In particular, surgeons were more likely to recommend TKA for patients with greater need, based on pain scores and ability to cope with symptoms, and in those with greater willingness to undergo the procedure.

However, knee replacement surgeons were less likely to recommended surgery for patients with more-demanding expectations, such as returning to sports or other vigorous activities. Consistent with the increased complication risk due to smoking, orthopedic surgeons were less likely to recommend TKA for patients who smoked.

Thus when all TKA appropriateness criteria were taken into account, "patient age was not associated with surgeons' TKA recommendations." At a time when TKA rates are rising fastest in patients less than 60 years old, "Incorporation of TKA appropriateness criteria into TKA decision-making may facilitate consideration of TKA benefits and risks in a growing population of young, obese individuals with knee OA," the researchers write.

Dr. Hawker adds: "Whether the short- and longer-term risks of TKA are outweighed by the benefits is unclear and warrants additional research."

Click here to read “The Effect of Patient Age and Surgical Appropriateness and Their Influence on Surgeon Recommendations for Primary TKA A Cross-Sectional Study of 2,037 Patients“

DOI: 10.2106/JBJS.21.00597


About The Journal of Bone & Joint Surgery

The Journal of Bone & Joint Surgery (JBJS) has been the most valued source of information for orthopaedic surgeons and researchers for over 125 years and is the gold standard in peer-reviewed scientific information in the field. A core journal and essential reading for general as well as specialist orthopaedic surgeons worldwide, The Journal publishes evidence-based research to enhance the quality of care for orthopaedic patients. Standards of excellence and high quality are maintained in everything we do, from the science of the content published to the customer service we provide. JBJS is an independent, non-profit journal.

About Wolters Kluwer

Wolters Kluwer (WKL) is a global leader in professional information, software solutions, and services for the clinicians, nurses, accountants, lawyers, and tax, finance, audit, risk, compliance, and regulatory sectors. We help our customers make critical decisions every day by providing expert solutions that combine deep domain knowledge with advanced technology and services.

Wolters Kluwer reported 2020 annual revenues of €4.6 billion. The group serves customers in over 180 countries, maintains operations in over 40 countries, and employs approximately 19,200 people worldwide. The company is headquartered in Alphen aan den Rijn, the Netherlands.

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