News Release

Exercise improves health markers in young female survivors of childhood trauma

Strategy could alleviate cardiovascular and psychological effects of adverse childhood experiences

Peer-Reviewed Publication

Experimental Biology

Nathaniel Jenkins, PhD

image: Nathaniel Jenkins, PhD view more 

Credit: Nathaniel Jenkins, PhD

Philadelphia (April 2, 2022)—New research shows a progressive exercise training program mitigates some physiological and psychological effects of adverse childhood experiences (ACE) in otherwise healthy young women. These experiences are linked to “lasting, negative effects on health, well-being, as well as life opportunities,” according to the U.S. Centers for Disease Control and Prevention. The study will be presented this week at the American Physiological Society annual meeting at Experimental Biology (EB) 2022.  

ACEs are potentially traumatic events that occur before the age of 18, such as abuse, neglect or the loss of a parent. Roughly 61% of U.S. adults report experiencing at least one ACE, and about 16% report experiencing four or more. ACEs increase the risk of a range of chronic illnesses, including heart disease and mental health problems.

The researcher team split 42 otherwise healthy young adult women into three groups, one experimental and two controls. The experimental group comprised 14 young women who experienced at least four ACEs, as did one control group. The other control group was made up of young women who did not experience any ACEs.

The experimental group participated in a moderate-high intensity progressive exercise program. The program consisted of two days of aerobic and two days of resistance exercise per week. The resistance training steadily increased in weight as participants reached set milestones.

Participants showed improvement in two markers of cardiovascular health and two markers of psychological well-being. Their systolic blood pressure—the upper number in a blood pressure reading—went down, as did their levels of endothelin-1, a peptide that triggers constriction of blood vessels. They also showed improved goal-planning, which is a sub-type of the psychological measure of hope. Notably, the researchers observed a connection between the physiological and psychological outcomes “suggesting a potential psychophysiological relationship between positive psychological traits and cardiovascular risk factors in young women with ACEs.”

“Our data may point to an important cardiovascular psycho-physiological connection in young adult women who have experienced significant childhood psychosocial stress that can be improved via participation in structured, progressive exercise training,” researchers wrote.


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About Experimental Biology 2022

Experimental Biology is the annual meeting of five societies that explores the latest research in physiology, anatomy, biochemistry and molecular biology, investigative pathology and pharmacology. With a mission to share the newest scientific concepts and research findings shaping clinical advances, the meeting offers an unparalleled opportunity for global exchange among scientists who represent dozens of scientific areas, from laboratory to translational to clinical research.


About the American Physiological Society

Physiology is a broad area of scientific inquiry that focuses on how molecules, cells, tissues and organs function in health and disease. The American Physiological Society connects a global, multidisciplinary community of more than 10,000 biomedical scientists and educators as part of its mission to advance scientific discovery, understand life and improve health. The Society drives collaboration and spotlights scientific discoveries through its 16 scholarly journals and programming that support researchers and educators in their work.

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