News Release

Insomnia is linked with recurrent heart events in coronary patients

Peer-Reviewed Publication

European Society of Cardiology

Sophia Antipolis – 7 April 2022:  Nearly half of heart disease patients have insomnia, according to research presented at ESC Preventive Cardiology 2022, a scientific congress of the European Society of Cardiology (ESC),1 and published in SLEEP Advances.2

“Sleep problems are linked to mental health issues, but our study found that insomnia was still significantly associated with heart events even after accounting for symptoms of anxiety and depression,” said lead author Lars Frojd, a medical student at the University of Oslo, Norway. “The findings suggest that heart patients should be assessed for insomnia and offered appropriate management.”

The prospective study included 1,068 consecutive patients an average of 16 months after a heart attack and/or a procedure to open blocked arteries (stent implantation or bypass surgery). Data on insomnia, risk factors for repeat heart events, and co-existing conditions were collected at baseline.

Participants completed the Bergen Insomnia Scale questionnaire which is based on the diagnostic criteria for insomnia.3 Six questions cover the ability to fall asleep and stay asleep, waking up prematurely, feeling inadequately rested, tiredness during the day that affects ability to function at work or socially, and being dissatisfied with sleep.

The risk factors included C-reactive protein (a marker of inflammation), smoking status, low-density lipoprotein (LDL) cholesterol, diabetes, physical activity, waist circumference, and systolic blood pressure. The co-existing conditions were stroke, transient ischaemic attack, peripheral artery disease, and kidney failure.

Patients were followed for the primary composite endpoint of major adverse cardiovascular events (MACE), defined as cardiovascular death, hospitalisation due to myocardial infarction, revascularisation, stroke or heart failure. Outcome data were obtained from hospital records.

Approximately one in five participants (21%) were women. At baseline, the average age of patients was 62 years, almost half (45%) had insomnia and 24% had used sleep medication in the past week. During an average follow-up of 4.2 years, a total of 364 MACE occurred in 225 patients.

Compared to those without insomnia, the relative risk of recurrent MACE in patients with insomnia was 1.62 after adjusting for age and sex, 1.49 after additional adjustment for coronary risk factors, and 1.48 after also adjusting for co-existing conditions. The association between insomnia and recurrent MACE remained significant when symptoms of anxiety and depression were also adjusted for, with a relative risk of 1.41.

Insomnia accounted for 16% of recurrent MACE in attributable risk fraction analyses, being third in importance after smoking (27%) and low physical activity (21%). Mr. Frojd said: “This means that 16% of recurrent major adverse cardiovascular events might have been avoided if none of the participants had insomnia.”

He concluded: “Our study indicates that insomnia is common in heart disease patients and is linked with subsequent cardiovascular problems regardless of risk factors, co-existing health conditions and symptoms of mental health. Further research is needed to examine whether insomnia treatments such as cognitive behavioural therapy and digital applications are effective in this patient group.”



Authors: ESC Press Office

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Notes to editor


This was a joint project of the University of Oslo (the Institutes of Clinical Medicine and Psychology) and the Norwegian Coronary Prevention (NOR-COR) research group.


Funding: The study was funded by the University of Oslo and the Norwegian Coronary Prevention (NOR-COR) research group at Vestre Viken Trust, Drammen Hospital.


Disclosures: None.


References and notes

1The abstract ‘Insomnia was associated with increased risk of recurrent cardiovascular events in coronary heart disease patients’ will be presented during the session ‘Rapid fire abstracts session 1 - Secondary Prevention and Rehabilitation’ which takes place on 7 April at 18:00 CEST.

2 Aastebol Frojd et al. Insomnia as a predictor of recurrent cardiovascular events in patients with coronary heart disease. SLEEP Advances. 2022 (doi:10.1093/sleepadvances/zpac007)

3Pallesen S, Bjorvatn B, Nordhus IH, et al. A new scale for measuring insomnia: the Bergen Insomnia Scale. Percept Mot Skills. 2008;107:691–706.


About the European Association of Preventive Cardiology

The European Association of Preventive Cardiology (EAPC) is a branch of the ESC. Its mission is to promote excellence in research, practice, education and policy in cardiovascular health, primary and secondary prevention.


About ESC Preventive Cardiology 2022  #ESCPrev2022

ESC Preventive Cardiology 2022, formerly EuroPrevent, is the leading international congress on preventive cardiology and the annual congress of the European Association of Preventive Cardiology (EAPC) of the European Society of Cardiology (ESC).


About the European Society of Cardiology

The European Society of Cardiology brings together health care professionals from more than 150 countries, working to advance cardiovascular medicine and help people lead longer, healthier lives.


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