News Release

Multicenter study of ultrasound LI-RADS suggests switch for HCC surveillance

Only 42% of patients with visualization score C on surveillance exam have score C on follow-up exam

Peer-Reviewed Publication

American Roentgen Ray Society

69-Year-Old Man With Chronic Hepatitis B

image: (A) Transverse gray-scale ultrasound image shows inability to visualize portion of liver. Examination received visualization score C. (B) Transverse gray-scale ultrasound image from examination performed 9 months later shows improved visualization of liver. Examination received visualization score A. view more 

Credit: American Roentgen Ray Society (ARRS), American Journal of Roentgenology (AJR)

Leesburg, VA, April 6, 2022According to ARRS’ American Journal of Roentgenology (AJR), findings from a multicenter study of ACR ultrasound LI-RADS visualization scores on serial examinations may inform decisions to switch to alternative surveillance strategies in patients at risk for HCC with visualization score C.

Noting any decision should consider the number of previous examinations with score C, “only 42% of patients with visualization score C on surveillances examination have score C on follow-up examination,” wrote corresponding author Aya Kamaya from the department of radiology at Stanford University School of Medicine in California.

Kamaya and colleagues’ retrospective study included patients at risk for HCC who underwent at least two HCC surveillance ultrasound examinations between January 2017 and November 2020 at Stanford University Medical Center and two institutions in Dallas, TX: University of Texas Southwestern Medical Center and Parkland Health and Hospital System. Frequencies of score remaining unchanged after variable numbers of preceding examinations with the given score were determined.

Ultimately, the probability of repeat visualization score C on a subsequent examination increased with an increasing number of preceding examinations with score C. Frequency of score C was 42%, 67%, and 80% after 1, 2, and 3 consecutive preceding examinations with score C.

“Although not statistically significant,” the authors of this AJR article acknowledged, “presence of severe steatosis and advanced cirrhosis had the highest odds ratios (2.88 and 2.38, respectively) for repeat score C in multivariable analysis.”

North America’s first radiological society, the American Roentgen Ray Society (ARRS) remains dedicated to the advancement of medicine through the profession of medical imaging and its allied sciences. An international forum for progress in radiology since the discovery of the x-ray, ARRS maintains its mission of improving health through a community committed to advancing knowledge and skills with the world’s longest continuously published radiology journal—American Journal of Roentgenology—the ARRS Annual Meeting, InPractice magazine, topical symposia, myriad multimedia educational materials, as well as awarding scholarships via The Roentgen Fund®.


Logan K. Young, PIO

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