News Release

“Promising evidence” that osteopathy may relieve musculoskeletal pain

Peer-Reviewed Publication

BMJ Group

There’s “promising evidence” that osteopathy, the physical manipulation of the body’s tissues and bones, may relieve the pain associated with musculoskeletal conditions, finds a review of the available clinical evidence, published in the open access journal BMJ Open.

But there’s little or only inconclusive evidence to back its use in children, and for the treatment of migraine or irritable bowel syndrome (IBS), the findings show.

Osteopathy, which was first developed in the late 1800s in the USA, is based on the principle that the structure (anatomy) and function (physiology) of a person’s body are intertwined. It aims to repair imbalances in this relationship.

In common with other forms of complementary medicine, osteopathy has grown in popularity over the past decade, particularly for the treatment of musculoskeletal disorders. The researchers therefore wanted to assess its safety and effectiveness for different conditions. 

They trawled research databases for systematic reviews and pooled data analyses (meta analyses) of relevant randomised controlled clinical trials, published up to November 2021. 

Only trials carried out by doctors with osteopathic training or osteopaths were included.

The search uncovered nine systematic reviews or meta analyses conducted between 2013 and 2020, involving 55 primary trials and 3740 participants. 

The systematic reviews reported on the use of osteopathy in a wide range of conditions, including acute and chronic non-specific low back pain, chronic non-specific neck pain, chronic non-cancer pain, primary headache, and IBS.

The pooled data analyses reported that osteopathy is more effective than other approaches in reducing pain and improving physical function in acute/chronic non-specific lower back and neck pain and in chronic pain not associated with cancer. 

The other comparative approaches included dummy treatment (placebo), sham osteopathy, light touch therapy, no treatment, waiting list, conventional treatment, physiotherapy or other forms of complementary medicine.

But small sample size, contradictory findings, and wide variations in study design meant that the evidence on the effectiveness of osteopathy for use in children with various conditions, ranging from attention deficit hyperactivity disorder to asthma and infantile colic, and the treatment of migraine and IBS, was limited or inconclusive.

No serious side effects associated with the therapy were reported in the 7 systematic reviews that evaluated them, although only two defined how these were measured.

“This overview suggests that [osteopathy] could be effective in the management of musculoskeletal disorders, specifically with regard to [chronic non-specific low back pain] and [low back pain ] in pregnant women or [those who have just had a baby],” write the researchers. 

“In contrast, inconclusive evidence was derived from [systematic reviews] analysing osteopathy efficacy on paediatric conditions, primary headache, and IBS,” they add. 

“Nevertheless, based on the low number of studies, some of which are of moderate quality, our overview highlights the need to perform further well-conducted [systematic reviews] as well as clinical trials (which have to follow the specific guidelines for non-pharmacological treatments) to confirm and extend the possible use of [osteopathy] in some conditions as well as its safety,” they conclude.

Notes for editors
Research: Efficacy and safety of osteopathic manipulative treatment: an overview of systematic reviews  doi 10.1136/bmjopen-2021-053468
Journal: BMJ Open

Funding: None declared

Link to AMS press release labelling system 

Embargoed link to research
Public link once embargo lifts

Author contact
Dr Donatella Bagagiolo, Research Department, Scuola Superiore di Osteopatia Italiana, Turin, Italy.
Tel: + 39 34 05 58 78 18

About the journal
BMJ Open is BMJ's first online general medical journal dedicated solely to publishing open access research. All its articles, supplementary files, and peer reviewers' reports are fully and openly available online, along with an increasing number of linked raw data sets in the Dryad repository(

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.