News Release

DWI for detection of locally recurrent pancreatic cancer

Adding diffusion-weighted MRI to conventional MRI improves the differentiation of locally recurrent tumor and post-surgical fibrosis after pancreatic ductal adenocarcinoma resection

Peer-Reviewed Publication

American Roentgen Ray Society

48-year-old man who underwent pylorus-preserving pancreatoduodectomy with superior mesenteric vein resection and reconstruction for pancreatic ductal adenocarcinoma (T3N1)

image: A. Axial contrast-enhanced CT image shows 1.7 cm lesion (arrow) with ill-defined margin at left side of superior mesenteric artery. B. On axial T2-weighted image, mass is hyperintense to paravertebral muscle (arrow). C. On arterial phase post-contrast T1-weighted image, mass shows mild enhancement (arrow) compared to unenhanced image; enhancement pattern classified as early. D. On DWI with b-value of 800 mm2/s, mass is hyperintense (arrow) to paravertebral muscle. E. On ADC map, mass is visually hypointense (arrow) to paravertebral muscle. Findings indicate presence of qualitative diffusion restriction; lesion ADC value was 0.96 × 10−3 mm2/s. F. Axial image from CT performed 6 months after MRI shows increase in lesion’s greatest axial diameter by more than 5 mm (arrow), indicating soft tissue abnormality represents locally recurrent tumor. view more 

Credit: American Roentgen Ray Society (ARRS), American Journal of Roentgenology (AJR)

Leesburg, VA, May 25, 2022According to ARRS’ American Journal of Roentgenology (AJR), adding diffusion-weighted MRI (DWI) to conventional MRI improves the differentiation of locally recurrent tumor and post-surgical fibrosis after pancreatic ductal adenocarcinoma (PDAC) resection, primarily due to improved sensitivity for recurrence.

“The findings indicate a potential role for MRI with DWI in surveillance protocols after PDAC resection,” clarified corresponding author Tae Wook Kang, MD from Samsung Medical Center in Seoul, South Korea.

Kang and colleagues’ retrospective study included 66 patients (35 men, 31 women; mean age, 60.5 years) with PDAC resection between January 2009 and March 2016, who underwent postoperative surveillance CT demonstrating a soft tissue lesion at the operative site or at the site of peripancreatic vessels and subsequent MRI with DWI for further evaluation. CT at least 6 months after MRI served as reference standard, with increase in size of the soft tissue by ≥5 mm differentiating locally recurrent tumor (n=26) and post-surgical fibrosis (n=40). Two observers independently reviewed MRI examinations in separate sessions: conventional MRI alone vs MRI with DWI.

Compared with MRI alone, MRI and DWI showed higher sensitivity (observer 1: 88.5% vs 61.5%, p=.008; observer 2: 84.6% vs 42.3%, p= .001) without difference in specificity (observer 1: 72.5% vs 80.0%, p=.08; observer 2, 95.0% vs 85.0%, p=.10) in detecting local recurrence after PDAC resection.

“MRI with DWI as a problem-solving tool during post-operative surveillance after PDAC resection could facilitate earlier detection of recurrences,” the authors of this AJR article added, “guiding prognostic assessment and treatment decisions.”

North America’s first radiological society, the American Roentgen Ray Society (ARRS) remains dedicated to the advancement of medicine through the profession of medical imaging and its allied sciences. An international forum for progress in radiology since the discovery of the x-ray, ARRS maintains its mission of improving health through a community committed to advancing knowledge and skills with the world’s longest continuously published radiology journal—American Journal of Roentgenology—the ARRS Annual Meeting, InPractice magazine, topical symposia, myriad multimedia educational materials, as well as awarding scholarships via The Roentgen Fund®.


Logan K. Young, PIO

44211 Slatestone Court

Leesburg, VA 20176


Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.