A new study presents a novel approach to drug repurposing that incorporates two-stage prediction and machine learning. The study is published in the peer-reviewed OMICS: A Journal of Integrative Biology. Click here to read the article now.
Drug repurposing is a method of developing new therapeutic use(s) for existing drugs, for which safety and pharmacokinetics have already been demonstrated in humans. This can significantly reduce the time, cost, uncertainty, and side effects associated with drug development.
Toshinori Endo, PhD, from Hokkaido University, and coauthors, propose a two-stage approach to drug repurposing. First, diseases are clustered by gene expression, with the thought that similar patterns of altered gene expression imply critical pathways shared in different disease conditions. Second, drug efficacy is determined based on the ability to reverse altered gene expression, and the results are clustered to identify repurposing targets. The investigators applied their approach and identified disease-specific gene expression and 20 drugs for repurposing.
“In this study, we took advantage of the large-scale identification and integration of different levels of information and biological insights that machine learning offers,” stated the investigators. “The efficiency and accuracy of drug candidate calculations were superior to those of previous studies, effectively improving the likelihood of successful drug repurposing, since all drugs were derived from agents effective against other diseases that clustered together in the same group.”
“Drug repurposing is of interest for therapeutics innovation in many human diseases including COVID-19. This study brings together three strands of methodological innovation: machine learning, unsupervised clustering of gene expression, and two-stage prediction. It is a timely contribution to the drug repurposing scholarship that should broadly inform life sciences discoveries, clinical trials, and translational medicine,” says Vural Özdemir, MD, PhD, DABCP, Editor-in-Chief of OMICS.
About the Journal
OMICS: A Journal of Integrative Biology is an authoritative and highly innovative peer-reviewed interdisciplinary journal published monthly online, addressing the latest advances at the intersection of postgenomics medicine, biotechnology and global society, including the integration of multi-omics knowledge, data analyses and modeling, and applications of high-throughput approaches to study complex biological and societal problems. Public policy, governance and societal aspects of the large-scale biology and 21st century data-enabled sciences are also peer-reviewed. Complete tables of content and a sample issue may be viewed on the OMICS: A Journal of Integrative Biology website.
About the Publisher
Mary Ann Liebert, Inc., publishers is known for establishing authoritative peer-reviewed journals in many areas of science and biomedical research. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s more than 100 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.
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