News Release

Tribeca Film Festival to debut documentary tracing the path to Penn Medicine and Children’s Hospital of Philadelphia’s transformative, personalized cancer therapy

“Of Medicine and Miracles” details the journey of a team of doctors and a family who came together on the leading edge of a cancer cure

Business Announcement

University of Pennsylvania School of Medicine

Team Photo

image: The cast of Of Medicine and Miracles gathered last month with director Ross Kauffman and producer Robin Honan to celebrate Emily Whitehead’s 10-year anniversary of being cancer-free. view more 

Credit: Penn Medicine

PHILADELPHIA – The behind-the-scenes story detailing the pursuit of a transformative cancer cure will unfold onscreen at the Tribeca Film Festival in New York City this weekend. “Of Medicine and Miracles,” which will premiere during the renowned international festival, is an emotional journey, revealing decades of research – and one young patient’s family’s last hopes to save their daughter – that culminated in the world’s first CAR T-cell therapy, an approach that reprograms patients’ own immune cells to kill their cancer.

From Oscar-winning director Ross Kauffman and Oscar-nominated producer Robin Honan, the documentary follows three paths which come together in what became a pivotal moment in cancer history. The film traces the life and work of physician-scientist Carl June, MD, whose vision laid the path for the revolutionary therapy, and the team of doctors and researchers at Penn Medicine and Children’s Hospital of Philadelphia (CHOP) who joined forces over laboratory benches and hospital beds to architect the bold approach to treating patients who’d run out of conventional options. Their paths crossed in 2012 with a six-year-old leukemia patient Emily Whitehead, whose family was hoping for a lifesaving miracle when they joined the clinical trial at CHOP that would make her the first child to receive the experimental treatment, which had previously been tested in just a small handful of adults at Penn Medicine’s Abramson Cancer Center.

Told “through bracingly honest interviews and home videos,” Tribeca Film Festival Director Cara Cusumano called the film “a tear-jerking, heart-racing record of medical history that honors its subjects and their trauma while empowering future generations to attempt the impossible.”

“Of Medicine and Miracles” was 10 years in the making, building on the 2012 short film “Fire with Fire,” which went viral after being posted on Upworthy, a website dedicated to positive storytelling.

In addition to Carl June, who is the director of the Center for Cellular Immunotherapies and the Richard W. Vague Professor in Immunotherapy, “Of Medicine and Miracles” also features Penn Medicine’s Bruce Levine, PhD, the Barbara and Edward Netter Professor in Cancer Gene Therapy and the Founding Director of the Clinical Cell and Vaccine Production Facility, and David Porter, MD, director of Cell Therapy and Transplantation in the Abramson Cancer Center and the Jodi Fischer Horowitz Professor in Leukemia Care Excellence. Children’s Hospital of Philadelphia physicians Stephan Grupp, MD, PhD, Section Chief of the Cellular Therapy and Transplant Section and Inaugural Director of the Susan S. and Stephen P. Kelly Center for Cancer Immunotherapy, and Susan Rheingold, MD, Medical Director of the Oncology Outpatient Clinic are also highlighted.

Kauffman’s documentary film credits include the Oscar-winning “Born into Brothels,” “E-TEAM,” and “Tigerland.” Honan received an Oscar nomination for the documentary “Mondays at Racine” and co-produced the Oscar-winning “Freeheld.”

To learn more, visit the Tribeca Film Festival website.


About Penn Medicine:


Penn Medicine is one of the world’s leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation’s first medical school) and the University of Pennsylvania Health System, which together form a $9.9 billion enterprise.

The Perelman School of Medicine has been ranked among the top medical schools in the United States for more than 20 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $546 million awarded in the 2021 fiscal year.


The University of Pennsylvania Health System’s patient care facilities include: the Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center—which are recognized as one of the nation’s top “Honor Roll” hospitals by U.S. News & World Report—Chester County Hospital; Lancaster General Health; Penn Medicine Princeton Health; and Pennsylvania Hospital, the nation’s first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners, Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.


Penn Medicine is powered by a talented and dedicated workforce of more than 47,000 people. The organization also has alliances with top community health systems across both Southeastern Pennsylvania and Southern New Jersey, creating more options for patients no matter where they live.


Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2021, Penn Medicine provided more than $619 million to benefit our community.


About Children’s Hospital of Philadelphia:

A non-profit, charitable organization, Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals, and pioneering major research initiatives, the 595-bed hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country. The institution has a well-established history of providing advanced pediatric care close to home through its CHOP Care Network, which includes more than 50 primary care practices, specialty care and surgical centers, urgent care centers, and community hospital alliances throughout Pennsylvania and New Jersey, as well as a new inpatient hospital with a dedicated pediatric emergency department in King of Prussia. In addition, its unique family-centered care and public service programs have brought Children's Hospital of Philadelphia recognition as a leading advocate for children and adolescents. For more information, visit



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