News Release

New review paper proposes framework for advancing application of animal-to-human transplantation

Peer-Reviewed Publication

American College of Cardiology

Central Illustration: The Barriers to Xenotransplantation Translation Into the Clinical Realm

image: Central illustration depicting xenotransplantation immunological and technical barriers, infectious barriers, physiological barriers, social and ethnical barriers, and health care resource-based barriers. view more 

Credit: Boulet J, et al. J Am Coll Cardiol Basic Trans Science. 2022

“The potential for xenotransplantation to allow for an unlimited donor supply and resolve the organ shortage is now closer than ever,” according to a new paper published today in JACC: Basic to Translational Science. Approximately one in 20 heart failure patients will progress to an advanced heart failure stage each year. The growing need for heart transplantations combined with a shortage of suitable donor organs has spurred research interest in xenotransplantation.

In January 2022, a 57-year-old heart failure patient successfully underwent transplantation surgery to receive a genetically engineered porcine heart; the patient survived for approximately two months. In this review, the study authors discuss the 2022 clinical case, along with the innovations, advances, challenges and barriers to successfully transplanting animal hearts into human subjects.

To review an embargoed copy of the paper, or to speak with an outside expert for comments, contact Sam Roth at In addition, a copy of the paper’s central illustration is available.


The American College of Cardiology envisions a world where innovation and knowledge optimize cardiovascular care and outcomes. As the professional home for the entire cardiovascular care team, the mission of the College and its more than 56,000 members is to transform cardiovascular care and to improve heart health. The ACC bestows credentials upon cardiovascular professionals who meet stringent qualifications and leads in the formation of health policy, standards and guidelines. The College also provides professional medical education, disseminates cardiovascular research through its world-renowned JACC Journals, operates national registries to measure and improve care, and offers cardiovascular accreditation to hospitals and institutions. For more, visit

The ACC’s family of JACC Journals rank among the top cardiovascular journals in the world for scientific impact. The flagship journal, the Journal of the American College of Cardiology (JACC) — and family of specialty journals consisting of JACC: Advances, JACC: Asia, JACC: Basic to Translational Science, JACC: CardioOncology, JACC: Cardiovascular Imaging, JACC: Cardiovascular Interventions, JACC: Case Reports, JACC: Clinical Electrophysiology and JACC: Heart Failure — pride themselves on publishing the top peer-reviewed research on all aspects of cardiovascular disease. Learn more at


Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.