News Release

For communication between brain areas, milliseconds matter

New study shows brain area communication changes faster than previously thought

Peer-Reviewed Publication

Sainsbury Wellcome Centre

Two visual areas in the cerebral cortex, V1 and LM, influence one another over fast timescales

image: Measuring changes in the activity of neurons in a cortical area while perturbing the activity in another area view more 


Understanding how brain areas communicate is one of the oldest questions in neuroscience. Researchers at the Sainsbury Wellcome Centre at UCL used causal techniques to uncover how two neocortical areas in the brain communicate with one another and found that their influence on each other changes over much faster-timescales than previously thought.

With around 80 billion neurons and 100 trillion connections in the brain, it has been challenging for neuroscientists to untangle the networks that give rise to behaviour. In a new study, published today in Neuron, SWC researchers elucidate how two visual areas in the cerebral cortex, the primary visual cortex (V1) and lateromedial area (LM), influence one another and how this communication changes over rapid timespans.

“We wanted to study the communication between areas to understand how different brain regions work together to process visual stimuli. From classical studies, we know that there is a hierarchy of visual areas with feedforward and feedback pathways. The first level of hierarchy in the cerebral cortex is V1 and the second level is V2 in primates, the equivalent of which is LM in mice,” said Mitra Javadzadeh, Research Fellow at SWC and co-author on the paper.

“Our expectation from the anatomical connections between V1 and LM is that the effect of neuronal activity in one area on another would be relatively constant; however, we were surprised to find it is dynamic and changes over time. These changes can happen very rapidly, within tens of milliseconds,” said Sonja Hofer, Group Leader at SWC and co-author on the paper.

Historically, scientists have recorded from different brain areas and used statistical correlations to infer how one area influences another. In this study, Javadzadeh and Hofer instead took a causal approach by using neuronal perturbations to study the dynamics of inter-areal interactions over time.

The neuroscientists recorded from populations of neurons in V1 and LM in mice and used optogenetics to briefly silence the activity of one area and quantify how the activity increased or decreased in the other area. This showed them the contribution of the first area in shaping the firing rates of the second area.

Javadzadeh and Hofer measured these contributions over time while these brain areas were processing visual information. Surprisingly, they found that the effect of manipulating one area on the activity in another varied over time on a fast timescale. For example, a neuron in area V1 could decrease its activity in response to area LM at one time point but not be influenced by LM activity 100 milliseconds later. Furthermore, if the visual stimulus was behaviourally relevant for the animal, for example if it was predicting the occurrence of a reward, then these changes in influence occurred even faster.

The function of these rapidly changing influences is not yet known, but the authors hypothesise that they may allow cortical areas to control different aspects of processing in the downstream brain regions they influence over very short time spans. This would mean that the role individual areas play in shaping each other’s activity could be flexible and tailored to the dynamic demands of behaviour.

In addition to exploring the function of these dynamic interactions, Javadzadeh and Hofer are working together with scientists at the Gatsby Computational Neuroscience Unit, located within the same building as SWC, to understand the mechanisms by which they come about.

This research was funded by the Sainsbury Wellcome Centre Core Grant from the Gatsby Charity Foundation and Wellcome (090843/F/09/Z), by an ERC Starting Grant (SBH, HigherVision 337797) and by Biozentrum, University of Basel core funds.


Read the full paper in Neuron: ‘Dynamic causal communication channels between neocortical areas’

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For more information or to speak to the researchers involved, please contact:

April Cashin-Garbutt
Head of Research Communications and Engagement, Sainsbury Wellcome Centre
E: T: +44 (0)20 3108 8028

About the Sainsbury Wellcome Centre
The Sainsbury Wellcome Centre (SWC) brings together world-leading neuroscientists to generate theories about how neural circuits in the brain give rise to the fundamental processes underpinning behaviour, including perception, memory, expectation, decisions, cognition, volition and action. Funded by the Gatsby Charitable Foundation and Wellcome, SWC is located within UCL and is closely associated with the Faculties of Life Sciences and Brain Sciences. For further information, please visit:

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