News Release

Scientists to rewrite DNA to cure killer heart diseases

BHF to award £30m in “defining moment” for cardiovascular medicine

Grant and Award Announcement

British Heart Foundation

An injectable cure for inherited heart muscle conditions that can kill young people in the prime of their lives could be available within a few years, after an international team of researchers were announced as the winners of the British Heart Foundation’s Big Beat Challenge.  

The global award, at £30m, is one of the largest non-commercial grants ever given and presents a “once in a generation opportunity” to provide hope for families struck by these killer diseases.  

The winning team, CureHeart, will seek to develop the first cures for inherited heart muscle diseases by pioneering revolutionary and ultra-precise gene therapy technologies that could edit or silence the faulty genes that cause these deadly conditions.   

The team, made up of world-leading scientists from the UK, US and Singapore, was selected by an International Advisory Panel chaired by Professor Sir Patrick Vallance, Chief Scientific Advisor to the UK Government. 

Inherited heart muscle diseases can cause the heart to stop suddenly or cause progressive heart failure in young people. Every week in the UK, 12 people under the age of 35 die of an undiagnosed heart condition1, very often caused by one of these inherited heart muscle diseases, also known as genetic cardiomyopathies. Around half of all heart transplants are needed because of cardiomyopathy and current treatments do not prevent the condition from progressing. 

It’s estimated that one in 250 people worldwide - around 260,000 people in the UK - are affected by genetic cardiomyopathies, with a 50:50 risk they will pass their faulty genes on to each of their children. In many cases, multiple members of the same family will develop heart failure, need a heart transplant, or are lost to sudden cardiac death at a young age. 

BHF Professor Hugh Watkins, from the Radcliffe Department of Medicine at the University of Oxford and lead investigator of CureHeart, said: “This is our once-in-generation opportunity to relieve families of the constant worry of sudden death, heart failure and potential need for a heart transplant. After 30 years of research, we have discovered many of the genes and specific genetic faults responsible for different cardiomyopathies, and how they work. We believe that we will have a gene therapy ready to start testing in clinical trials in the next five years. 

“The £30 million from the BHF’s Big Beat Challenge will give us the platform to turbo-charge our progress in finding a cure so the next generation of children diagnosed with genetic cardiomyopathies can live long, happy and productive lives.” 

The team will take the revolutionary gene-editing technology of CRISPR to the next level by deploying ultra-precise techniques, called base and prime editing, in the heart for the first time. These ground-breaking approaches use ingenious molecules that act like tiny pencils to rewrite the single mutations that are buried within the DNA of heart cells in people with genetic cardiomyopathies. 

They will focus this technology on two areas. First, where the faulty gene produces an abnormal protein in the pumping machinery of the heart, the team will aim to correct or silence the faulty gene by re-writing the single spelling mistakes or switching off the entire copy of the faulty gene. 

Second, where the faulty gene does not produce enough protein for the heart muscle to work as it should, the team plan to increase the production of healthy heart muscle proteins by using genetic tools to correct the function of the faulty copy of the gene or to stimulate the normal copy of the gene. 

The team have already proven that these approaches are successful in animals with cardiomyopathies and in human cells. They believe the therapies could be delivered through an injection in the arm that would stop progression and potentially cure those already living with genetic cardiomyopathies. It could also be used to prevent the disease developing in family members who carry a faulty gene but have not yet developed the condition. 

Dr Christine Seidman at Harvard University and co-lead of CureHeart, said: “Acting on our mission will be a truly global effort. We’ve brought in pioneers in new, ultra-precise gene editing, and experts with the techniques to ensure we get our genetic tools straight into the heart safely. It’s because of our world-leading team from three different continents that our initial dream should become reality.” 

Professor Sir Nilesh Samani, Medical Director at the British Heart Foundation, said: “This is a defining moment for cardiovascular medicine. Not only could CureHeart be the creators of the first cure for inherited heart muscle diseases by tackling killer genes that run through family trees, it could also usher in a new era of precision cardiology. Once successful, the same gene editing innovations could be used to treat a whole range of common heart conditions where genetic faults play a major role. This would have a transformational impact and offer hope to the thousands of families worldwide affected by these devastating diseases.” 

Sir Patrick Vallance, Chair of the BHF’s International Advisory Panel and Government Chief Scientific Adviser, said: “CureHeart was selected in recognition of the boldness of its ambition, the scale of its potential benefit for patients with genetic heart muscle diseases and their families, and the excellence of the international team of participating researchers.” 

Dr Charmaine Griffiths, Chief Executive of the British Heart Foundation, said: “With the public’s support, the aim of the Big Beat Challenge was to move past incremental progress and make a giant leap in an important area of heart patient care. Creating the world’s first genetic cure for a heart disease would undoubtedly do this and has the potential to stop families losing loved ones without a moment’s notice to these cruel diseases. However, we need the continued backing of our supporters to turn science like this into a reality for the millions of people around the world living with heart disease.”  

Patient story – Max Jarmey, 27 

Max Jarmey was just 13 when his dad Chris died suddenly following a cardiac arrest, caused by a condition called arrhythmogenic right ventricular cardiomyopathy (ARVC, a type of genetic cardiomyopathy).  

A few years later Max was told that he had ARVC (which is now known as arrhythmogenic cardiomyopathy) following a routine screening appointment. Shortly after, his younger brother Tom was also diagnosed. Both had inherited the condition from their dad. 

Max describes himself as “obsessed with sport” growing up and he competed in mountain biking to a high level until 18, when his diagnosis meant he had to give it up.  

He said: “I’m pretty mentally robust but the first six months following my diagnosis were incredibly difficult. It was horrible to be told I had a condition like ARVC at the age I was told, and then to be forced to quit something I loved.” 

Now 27, Max tries to focus on what he can do rather than what his condition stops him doing. He has been fitted with an implantable cardioverter defibrillator (ICD), which has shocked his heart back into a normal rhythm after it’s gone into a life-threatening rhythm – protecting him from a cardiac arrest – many times over the years 

Max said: “I think the only way to deal with my ARVC is to accept it and the fact that I can’t control it. If I dwelt on it every day would be hard, but I do think about it often.” 

Professor Watkins diagnosed Max and has been his cardiologist ever since. Max said: “When Hugh told me about CureHeart I knew I wanted to be involved with something so inspiring. When I think about my future, the decision to have children and their future, CureHeart could make that decision easier. My children might never have to suffer like I have with this condition. That is completely life changing.   

“This project gives me hope. That’s what the BHF is funding – hope. This is not just about managing symptoms. CureHeart could be the cure for genetic cardiomyopathies.” 


To request interviews or for more information please call the BHF press office on 020 7554 0164 or email newsdesk at

Notes to editors 


About the British Heart Foundation 

It is only with donations from the public that the BHF can keep its life saving research going. Help us turn science fiction into reality. With donations from the public, the BHF funds ground-breaking research that will get us closer than ever to a world free from the fear of heart and circulatory diseases. A world where broken hearts are mended, where millions more people survive a heart attack, where the number of people dying from or disabled by a stroke is slashed in half. A world where people affected by heart and circulatory diseases get the support they need. And a world of cures and treatments we can’t even imagine today. Find out more at 

About the Big Beat Challenge award process 

The BHF’s Big Beat Challenge is a unique research funding award of £30m (around €35m, $36m USD) that was designed to galvanise the international research community to identify a real-world challenge, significant unmet need or opportunity for game-changing innovation in cardiovascular medicine. The BHF received 75 applications, featuring team members from 40 countries.  A patient and public panel gave their perspective, a special panel of independent researchers and medical professionals scrutinised the scientific rigour of the proposals, and the final decision was made by the International Advisory Panel comprised of leading international figures from the world of science, medicine and beyond. 

Find out more at 

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