Looking at the rise in infections caused by different MDR bacteria, it is essential to elucidate the basic mechanism of antibiotic resistance to discover effective methods for diagnosis and treatment of infections. The present book will provide the information regarding recent strategies involved in the diagnosis and treatment of infections caused by Multi Drug Resistant (MDR) bacteria. The volume includes the use of Molecular Probes for quantification of pathogenic bacteria. The use of pathogen-specific probes offers a faster alternative for pathogen detection and could improve the diagnosis of infection. It also includes the High Resolution Melting Analysis technique for the detection of multi-drug resistant pathogens. Rational Structural Based Drug Design is now a common method to identify a lead compound and take it forward for further development. The book “Current Developments in the Detection and Control of Multi Drug Resistance” also involves the use of this approach for identification of novel drug targets from Lipid A biosynthesis pathway of bacteria and also from quorum sensing mediated biofilm formation in MDR bacteria. Amoebiasis, also known amoebic dysentery, is an infection caused by any of the amoebae of the Entamoeba group. We have also highlighted the involvement of MDR bacterial infections during Amoebiasis and its cure. We have tried to cover the herbal alternative for the treatment of MDR bacteria involving use of Cassia aungustifolia in treatment of various diseases. This book solicits contribution will be useful for biomedical students, cellular and molecular biologists. It will be an ideal resource for student’s better understanding of MDR bacteria biology. We sincerely hope our efforts will be embraced by students with appreciation and enthusiasm for learning.
About the editors:
Dr Sanket Kaushik is an A/Professor at the Amity Institute of Biotechnology, Amity University, and Rajasthan. After obtaining his master's degree in 2008 from the University of Rajasthan, he received his Ph.D. degree in Biophysics from the Department of Biophysics, All India Institute of medical sciences, New Delhi. Currently, he is working on structural studies of protein drug targets from Multi Drug Resistant bacteria Enterococcus faecalis in its native state and complex with known and designed inhibitors. Enterococcus faecalis is a Gram positive multidrug resistant bacterium that is a common cause of hospital born infections. His major attention lies in investigating the details of host-pathogen interface through structural biology tools for understanding the mechanism of biofilm formation leading to the development of multi drug resistance. He has authored more than 50 research papers and many book chapters. Dr Kaushik has received research grant from several funding agencies in India. He has also worked as a member of the Biotech research society of India and as one of the founder members in Bio footprints. Dr. Kaushik is also working as an academic editor and a reviewer in many scientific journals of international repute.
Dr. Nagendra Singh is a professor of Biotechnology at Gautam Buddha University, Greater Noida, India. He obtained his postgraduate degree in Biochemistry from Jamia Hamdard University, New Delhi. He received his Ph.D. in the field of Structure Biology from All India Institute of Medical Sciences (AIIMS), New Delhi in 2004 from the Department of Biophysics. He has submitted over 200 PDB entries to the Protein Data Bank. After a few stints as a postdoctoral fellow/senior research officer/senior research associate at AIIMS, New Delhi, He was appointed at the School of Biotechnology, GBU in 2010. Dr. Singh has published over 70 peer-reviewed international research articles with a current H-index of 24. His current research interests include studies on RNA editing enzymes, antimicrobial proteins and drug design using structural biology approaches. Dr. Singh has been awarded by the National Academy of Sciences of India (NASI, Allahabad) young scientist award, Venus International Foundation Young Scientist Award, DST young scientist Award, Meeting of Noble Laureates and Students award in the field of medicine, Lindau, Germany by Govt of India and Best Ph.D. thesis award by AIIMS, New Delhi. Dr. Singh has also been awarded many travel awards from CCP4 UK, Indian National Science Academy, (INSA), Department of S&T, Department of Biotechnology and Council of Scientific and Industrial Research, etc. Dr. Singh is a member of the Indian Biophysical Society and Indian Crystallographic Association. He has been invited to many international and national conferences to present his research work.
Keywords:
Multi-drug resistant, Molecular techniques, pathogen-specific probes, Infectious diseases, High-Resolution Melting, Traditional medicines, Rational Structural Based Drug Design, ESKAPE pathogens, Drug targets, Drug discovery, Quorum Sensing, Drug repurposing, Biofilm, System biology, MDR Strategies, Structure biology, Antimicrobial Resistance, Antibiotics, PCR,Traditional methods.
For more information please visit: https://bit.ly/3RU5Sdg