RENTON, Wash. [Sept. 23, 2022] – A Providence study released online today in the Journal of the American Medical Association sheds new light on the added benefit of a booster dose of a COVID-19 mRNA vaccine among previously vaccinated individuals.
Researchers found that boosters add about 70% extra protection, which lasts for 4-5 months, and concluded that booster vaccination is associated with significantly decreased odds of hospitalization for COVID-19 among fully vaccinated individuals. Odds of decreased hospitalization varied based on time since booster administration.
While previous studies have established the association between boosters and decreased risk of developing severe COVID-19 when compared with unvaccinated individuals, this study is unique in its focus on individuals who are already fully vaccinated with the primary series of an mRNA vaccine. It adds to the growing body of research around the effect of booster doses in various populations.
This research shows us that even if you’re fully vaccinated, there’s a real value to getting a booster,” said Ari Robicsek, M.D., Providence’s chief medical analytics officer and senior author of the study. “Compared to people who only had their initial vaccinations, people with boosters were a lot less likely to have severe Covid for 4-5 months after the booster shot.”
Providence, a not-for-profit health system serving the Western U.S., conducted the research at sites across six western states. It matched 3,052 cases hospitalized for COVID-19 within a Providence facility 4:1 with 12,248 controls admitted to a Providence facility non-electively for reasons other COVID-19. Cases were hospitalized between October 1, 2021, and July 26, 2022, and controls were admitted to a facility within three days in the same geographic location as their case and received a second vaccine within seven days of their case.
Providence is a national, not-for-profit Catholic health system comprising a diverse family of organizations and driven by a belief that health is a human right. With 52 hospitals, over 900 physician clinics, senior services, supportive housing, and many other health and educational services, the health system and its partners employ more than 120,000 caregivers serving communities across seven states – Alaska, California, Montana, New Mexico, Oregon, Texas, and Washington, with system offices in Renton, Wash., and Irvine, Calif. Learn about our vision of health for a better world at Providence.org.
Method of Research
Subject of Research
Odds of Hospitalization for COVID-19 After 3 vs 2 Doses of mRNA COVID-19 Vaccine by Time Since Booster Dose
Article Publication Date
Dr Ridgway reported receiving personal fees from Gilead Sciences. Dr Diaz reported receiving grants from Gilead, Roche, Regeneron, Edesa Biotech Inc, Boehringer Ingelheim, NeuroBo Pharmaceuticals Inc, and the National Institutes of Health and serving as a scientific board member for Safeology. No other disclosures were reported.