https://doi.org/10.1016/j.apsb.2022.02.027
This new article publication from Acta Pharmaceutica Sinica B, discusses cooperative coordination-mediated multi-component self-assembly of “all-in-one” nanospike theranostic nano-platform for MRI-guided synergistic therapy against breast cancer.
Carrier-free multi-component self-assembled nano-systems have attracted widespread attention owing to their easy preparation, high drug-loading efficiency, and excellent therapeutic efficacy. The authors of this article generated a MnAs-ICG nanospike by self-assembly of indocyanine green (ICG), manganese ions (Mn2+), and arsenate (AsO43−) based on electrostatic and coordination interactions, effectively integrating the bimodal imaging ability of magnetic resonance imaging (MRI) and fluorescence (FL) imaging-guided synergistic therapy of photothermal/chemo/chemodynamic therapy within an “all-in-one” theranostic nano-platform. The as-prepared MnAs-ICG nanospike had a uniform size, well-defined nanospike morphology, and impressive loading capacities. The MnAs-ICG nanospike exhibited sensitive responsiveness to the acidic tumor microenvironment with morphological transformation and dimensional variability, enabling deep penetration into tumor tissue and on-demand release of functional therapeutic components. In vitro and in vivo results revealed that MnAs-ICG nanospike showed synergistic tumor-killing effect, prolonged blood circulation and increased tumor accumulation compared to their individual components, effectively resulting in synergistic therapy of photothermal/chemo/chemodynamic therapy with excellent anti-tumor effect.
Taken together, this new strategy might hold great promise for rationally engineering multifunctional theranostic nano-platforms for breast cancer treatment.
Article reference: Xiaojie Chen, Xudong Fan, Yue Zhang, Yinghui Wei, Hangsheng Zheng, Dandan Bao, Hengwu Xu, Ji-Gang Piao, Fanzhu Li, Hongyue Zheng, Cooperative coordination-mediated multi-component self-assembly of “all-in-one” nanospike theranostic nano-platform for MRI-guided synergistic therapy against breast cancer, Acta Pharmaceutica Sinica B, Volume 12, Issue 9, 2022, Pages 3710-3725, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2022.02.027
Keywords: Carrier-free nanodrugs, Self-assembly, Nanospike, Magnetic resonance imaging, Tumor microenvironment-responsive, Deep penetration, Synergistic therapy, Breast cancer
Graphical Abstract: available at https://ars.els-cdn.com/content/image/1-s2.0-S221138352200082X-ga1_lrg.jpg
An “all-in-one” theranostic nano-platform (MnAs-ICG nanospike), constructed by self-assembly via electrostatic and coordination interactions, has TME-responsive ability for deeper penetration, and can achieve bimodal imaging-guided synergistic therapy against breast cancer.
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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.
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CiteScore: 15.9
Impact Factor: 14.903
JIF without self-citation: 13.888
ISSN 2211-3835
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