News Release

Volunteers in COVID-19 human challenge trials are genuinely altruistic, not desperate for money or lacking understanding of the risks

Peer-Reviewed Publication


Participants in the volunteer group were asked to indicate their top three motivations for participating in a COVID-19 challenge trial from a list of ten options.

image: Selections were not ranked, and total percentages add to 300% because each participant selected 3 options. The two most commonly selected options were “I wanted to help others and potentially save lives” (95.9%) and “I wanted to contribute to the progress of medicine” (79.2%). view more 

Credit: Marsh et al., 2022, PLOS ONE, CC-BY 4.0 (

Article URL:

Article Title: Characterizing altruistic motivation in potential volunteers for SARS-CoV-2 challenge trials

Author Countries: USA, UK

Funding: This study was supported by 1Day Sooner in the form of a grant as part of the Open Philanthropy Project, and in the form of salaries for authors SMR, VS, & JM. This study was also supported by 1Day Sooner in the form of additional financial support for MP. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported by National Science Foundation in the form of grants for MM, NE (2039320) and AAM (1729406). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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