News Release

A rare gene variant in the X chromosome TLR7 gene is associated with a five times greater risk of severe COVID-19, in study of individuals across 12 countries

Peer-Reviewed Publication

PLOS

A rare gene variant in the X chromosome TLR7 gene is associated with a five times greater risk of severe COVID-19, in study of individuals across 12 countries

image: Maps of countries contributing data to the consortium. Sample sizes (cases and controls) for each phenotype were added and represented on the logarithmic scale by each circle. Relative contribution to each phenotype is represented by the three colors. Maps obtained from https://www.naturalearthdata.com/. view more 

Credit: Butler-Laporte G, et al., 2022, PLOS Genetics, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)

A rare gene variant in the X chromosome TLR7 gene is associated with a five times greater risk of severe COVID-19, in study of individuals across 12 countries

Article URL: http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010367

Article Title: Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative

Author Countries: Canada, United States, Italy, Qatar, Germany, Poland, Switzerland, United Kingdom, Spain, Japan, Sweden, Saudi Arabia, Thailand

Funding: see manuscript

Journal

PLoS Genetics

DOI

10.1371/journal.pgen.1010367

COI Statement

Competing Interests: see manuscript

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.