News Release

Dual-energy CT iodine concentration differentiates lung cancer from pulmonary metastases

Ringlike peripheral high iodine concentration maps from dual-energy CT (DECT) can help guide management in patients with known lung cancer and an indeterminate solitary nodule

Peer-Reviewed Publication

American Roentgen Ray Society

62-year-old man with history of oropharyngeal cancer, treated by chemoradiation therapy

image: Contrast-enhanced multiphase DECT of chest performed for surgical planning. Axial image from iodine concentration map, reconstructed from equilibrium-phase acquisition, shows thin ringlike peripheral high iodine concentration, involving nodule’s entire circumference. Nodule underwent resection, revealing oropharyngeal carcinoma metastasis. Case represents true-positive example of using ringlike peripheral high iodine concentration for diagnosis of pulmonary metastasis. view more 

Credit: ARRS/AJR

According to an accepted manuscript published in ARRS’ American Journal of Roentgenology (AJR), ringlike peripheral high iodine concentration maps from dual-energy CT (DECT) can help guide management in patients with known lung cancer and an indeterminate solitary nodule.

“Ringlike peripheral high iodine concentration had excellent interobserver agreement, showed high specificity (albeit poor sensitivity) for differentiating pulmonary metastasis from primary lung cancer, and independently predicted pulmonary metastasis,” wrote AJR first author Yoshinao Sato, MD, PhD, from the Diagnostic Imaging Center at Japan’s Cancer Institute Hospital in Tokyo.

This AJR accepted manuscript study included 93 patients (64 men, 29 women; median age, 70 years) who underwent resection of a primary lung cancer (n=68) or pulmonary metastasis (n=25) corresponding with a solid lesion on preoperative contrast-enhanced DECT performed between April 2020 and March 2021. After constructing venous-phase 120-keV single-energy images, equilibrium-phase 66-keV virtual monoenergetic images, as well as iodine concentration maps, two radiologists independently assessed lesions for the following: spiculated margins, air bronchograms, rim enhancement, and thin ringlike peripheral high iodine concentration.

Ultimately, ringlike peripheral high iodine concentration on DECT showed excellent interobserver agreement (κ=0.80), and had sensitivity of 52% and specificity of 81% for differentiating pulmonary metastases from primary lung cancers. Additionally, the finding independently predicted pulmonary metastasis in multivariate analysis [OR=7.81, 95% CI: 2.28–29.60; p=.001] combining patient and lesion characteristics.

“Iodine concentration maps from DECT could help determine the diagnosis for lesions that are equivocal for pulmonary metastasis on conventional images,” the authors of this AJR accepted manuscript reiterated.

North America’s first radiological society, the American Roentgen Ray Society (ARRS) remains dedicated to the advancement of medicine through the profession of medical imaging and its allied sciences. An international forum for progress in radiology since the discovery of the x-ray, ARRS maintains its mission of improving health through a community committed to advancing knowledge and skills with the world’s longest continuously published radiology journal—American Journal of Roentgenology—the ARRS Annual Meeting, InPractice magazine, topical symposia, myriad multimedia educational materials, as well as awarding scholarships via The Roentgen Fund®.


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