NO has emerged as a central regulator of energy metabolism and body composition. NO bioavailability is decreased in T2D. Several of the pharmaceuticals used in T2D affect the NO system and perhaps even more so by the drugs we use to treat diabetic cardiovascular complications. Experimental works in animal models of T2D show promising results with interventions aimed to increase NO signaling. However, translation into human studies has so far been less successful, but larger and more prolonged studies are clearly needed.
The book “The Role of Nitric Oxide in Type 2 Diabetes“ is a collection of reviews dealing with the part of Nitric Oxide in Type 2 Diabetes, providing a unique overview of NO signaling, and pointing out key areas for more detailed research. The book includes pathophysiology of T2D, a brief history of discovery and timeline of NO research, a comprehensive overview of impaired NO metabolism in T2D, precursors of NO (i.e., L-arginine, L-citrulline, nitrate, nitrites, and NO donors), NO and T2D from genetic points of view, NO and diabetic wound healing, NO and osteoporosis, NO and hyperuricemia, NO and Alzheimer’s Disease, therapeutic applications of NO and NO donors in T2D. The present book is of great value to anyone interested in field of NO and diabetes.
- Asghar Ghasaemi
- Khosrow Kashfi
- Zahra Bahadoran
Osteoprosis, Insulin resistance, Asymmetrical Dimethyl Arginine, Glucose, Nitric oxide synthase, Endothelium, Diabetes complications, Metabolic syndrome, Diabetes, Nitric oxide, Nitrate, Nitrite, L-arginine, L-citrulline, Wound healing, Microbiota, Genetics, Hyperuricemia.
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