News Release

Racial disparities in childhood adversity linked to brain structural differences in U.S. children

Study highlights the role structural racism may play in brain development and disparate rates of psychiatric disease among Black and White Americans

Peer-Reviewed Publication

McLean Hospital

Belmont, MA – Black children in the United States are more likely to experience childhood adversity than White children, and these disparities are reflected in differential changes to regions of the brain linked to psychiatric disease like posttraumatic stress disorder (PTSD), according to new research led by McLean Hospital, a member of Mass General Brigham.

The findings, published February 1 in the American Journal of Psychiatry, the flagship journal of the American Psychiatric Association, suggest that adversity may act as a toxic stressor to regions of the brain related to threat processing and that this exposure is disproportionately seen in Black children. The authors added that their study provides additional evidence contradicting the pseudoscientific falsehood that there are inherent race-related differences found in the brain and instead emphasizes the role of adversity brought on by structural racism.

For the study, led by Nathaniel Harnett, PhD, director of the Neurobiology of Affective Traumatic Experiences Laboratory at McLean Hospital, researchers analyzed surveys and MRI brain scans of more than 7,300 White children and nearly 1,800 Black children in the U.S. who were 9 and 10 years old. They found Black children displayed small neurobiological differences reflected as lower gray matter volumes in the amygdala, hippocampus and prefrontal cortex compared with White children. Their analysis also revealed that experiencing adversity was the significant differentiating factor, with household income the most common predictor of brain volume differences.

“Our research provides substantial evidence of the effects structural racism can have on a child’s developing brain, and these small differences may be meaningful for their mental health and wellbeing through adulthood,” said Dr. Harnett, who is also an Assistant Professor of Psychiatry at Harvard Medical School. “The dataset in our study included children younger than 10 years old – children who have no choice in where they are born, who their parents are and how much adversity they are exposed to. These findings offer another chilling reminder of the public health impact of structural racism, and how crucial it is to address these disparities in a meaningful way.”

Mining data for social determinants of adversity and impact on brain

In the US., there are stark racial disparities in the distribution of economic resources, exposure to stress, and psychiatric disorder prevalence. To date, limited research has investigated how racial inequities in the social determinants of health may lead to changes in the brain for different groups.

This led Dr. Harnett and colleagues at McLean’s Neurobiology of Fear Laboratory to leverage strong datasets to look for potential race-related differences in the neurobiology of psychiatric disorders and how racial structural inequities may explain these differences.

The researchers reviewed data from the 2019 Adolescent Brain and Cognitive Development (ABCD) Study, a large-scale MRI research effort that included nearly 12,000 U.S. children between the ages of 9 and 10 from 21 sites across the country. Study participants’ parents filled out surveys assessing parent and child race and ethnicity; parental education, employment and family income; and other variables. Children also completed assessments that captured emotional and physical conflicts within their household. Also included were measures of neighborhood disadvantage using the Area Deprivation Index, which utilizes 17 socioeconomic indicators from the U.S. Census, including poverty and housing, that characterize a given neighborhood.

The analysis found that White children’s parents were three times more likely to be currently employed than Black children’s parents. White children’s parents also attained a higher level of education and had greater family income compared with Black children’s parents. Specifically, about 75 percent of White parents had a college degree, compared with nearly 41 percent of Black parents, and about 88 percent of White parents made $35,000 a year or more, compared with about 47 percent of Black parents. White children also experienced less family conflict, less material hardship, less neighborhood disadvantage and fewer traumatic events compared with Black children.

When assessing corresponding MRI data, experiencing childhood adversity was associated with lower gray matter volumes in the amygdala, hippocampus and prefrontal cortex – effects more likely to be seen in Black children. The amygdala plays an important role in the learning of a fear response, the hippocampus in memory formation, and the prefrontal cortex is what regulates the emotional and threat response to fear. The researchers observed neurobiological effects tied to most adversity indicators with income being the most frequent predictor, affecting gray matter volume in eight of 14 regions of the brain studied. Trauma history and family conflict were not related to gray matter volume in any of the models; however, the researchers note that doesn’t necessarily reflect that there is no neurobiological impact from those adversities.

Additional analysis factoring in previous studies on PTSD and regions of the brain found Black children had significantly greater PTSD symptom severity, and symptom severity was further predicted by adversity.

“I consider these findings critically important, as they speak to the need for Psychiatry as a field to be outspoken about the detrimental psychological impacts of race-related disparities in childhood adversity, to call out the fact that these disparities stem from structural racism, and to vigorously support rectifying efforts by pursuing policy changes,” said Ned H. Kalin, MD, Editor-in-Chief of the American Journal of Psychiatry.

Future study of neurobiological impact of structural racism

Future research from this team will build upon these findings and expand their data collection beyond the ages included in this study in an effort to track the neurobiological impact racial disparities in adversity have throughout a lifetime. The researchers also hope to determine whether exposure to adversity may accelerate or decelerate aging in the brain, and whether additional measures of adversity not included in this study may impact these regions of the brain or others involved in psychiatric disorders.

“These findings may just be the tip of the iceberg,” said Dr. Harnett.

About McLean:
McLean Hospital has a continuous commitment to put people first in patient care, innovation and discovery, and shared knowledge related to mental health. It is consistently named the #1 freestanding psychiatric hospital in the United States by U.S. News & World Report, and is #1 in America for psychiatric care in 2022-23. McLean Hospital is the largest psychiatric affiliate of Harvard Medical School and a member of Mass General Brigham. To stay up to date on McLean, follow us on FacebookYouTube, and LinkedIn.

American Psychiatric Association

The American Psychiatric Association, founded in 1844, is the oldest medical association in the country. The APA is also the largest psychiatric association in the world with more than 37,000 physician members specializing in the diagnosis, treatment, prevention, and research of mental illnesses. APA's vision is to ensure access to quality psychiatric diagnosis and treatment. For more information, please visit

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