News Release

BrainHealth research demonstrates positive impact of online SMART training

Online delivery of established protocol reduces symptoms of depression, anxiety and stress

Peer-Reviewed Publication

Center for BrainHealth

The Strategic Memory Advanced Reasoning Tactics (SMART™) brain health training protocol has been shown to improve symptoms of depression, anxiety and stress when delivered in person. New research from Center for BrainHealth® at The University of Texas at Dallas demonstrates the effectiveness of online delivery of SMART.

SMART training features strategies to strengthen the brain’s frontal networks and achieve significant, measurable brain changes and improvements. This brain health training program promotes improvements in both trained and untrained areas of cognitive functioning, including strategic attention, innovation, working memory and real-life executive function behaviors. In addition to improving cognitive function, SMART has also demonstrated unexpected benefits in mental health markers.

The research, "Effects of Online Brain Training on Self-Reported Mental Health Symptoms for Generally Healthy Adults During the COVID-19 Pandemic," was published in Brain and Behavior.

This study investigated the effects of a 12-week, self-paced, online SMART training on mental health on 145 participants between the ages of 18-78 years. Participants included 106 females and 39 males. Participants self-reported mental health symptoms on the Depression Anxiety Stress Scale (DASS-21), a tool to measure the negative emotional states of depression, anxiety and tension/stress, both pre- and post- training. Although the participants consisted of healthy adults, some reported symptoms of psychological distress at baseline pre-training on the DASS-21, particularly in the younger age groups.

Improvements in depression, anxiety and stress symptoms were observed following online SMART, evidenced by a significant decrease in self-reported symptoms on the DASS-21. While SMART training generally yielded mental health benefits across age, gender and education levels, additional exploration is warranted to explore how age and education may affect expression of symptom subtypes.

The lasting impact of this training was revealed in data from 44 participants who completed a follow-up DASS-21 six months after the initial training and showed that improvement in self-reported mental health symptoms was maintained or continued to expand post-training. These findings suggest that SMART may be an effective tool to help those experiencing pre-clinical mental health symptoms, particularly for depression and stress.

Lead author Sarah Laane, MS, CCC-SLP, a research clinician and doctoral student at Center for BrainHealth, stated these findings indicate that participants who completed online SMART experienced similar mental health benefits to those previously demonstrated after in-person SMART programs and demonstrates support for the use of online SMART as a potential low-cost, high-impact tool to support mental health.

For more information on SMART, visit

Funding Statement: This work was funded by private philanthropy: The Baldridge Foundation, Jean Ann Brock, The Joshua M. and Inette S. Brown Family Foundation, Peggy Dear, Estate of Alice Janet DeSanders, Teresa and David Disiere, Folsom Charitable Foundation, Jane and Mark Gibson, The Carlos and Deborah Hernandez Foundation, The Hoglund Foundation, Kozmetsky Family Foundation, The J. Willard and Alice S. Marriott Foundation, J. Willard Marriott, Jr. Foundation, Shirley & William S. McIntyre Foundation, Ellen and John McStay, Marlane Miller, Laurie and Todd Platt, Gail and Bill Plummer, Jennifer and Peter Roberts, The Rouse Family Foundation, Sammons Enterprises, Inc., and Harold Simmons Foundation, as well as several anonymous donors.

CONTACT:Stephanie Hoefken



Center for BrainHealth®, part of The University of Texas at Dallas, is a translational research institute committed to enhancing, preserving, and restoring brain health across the lifespan. Major research areas include the use of functional and structural neuroimaging techniques to better understand the neurobiology supporting cognition and emotion in health and disease. This leading-edge scientific exploration is translated quickly into practical innovations to improve how people think, work and live, empowering people of all ages to unlock their brain potential. Translational innovations build on Strategic Memory Advanced Reasoning Tactics (SMART™), a proprietary methodology developed and tested by BrainHealth researchers and other teams over three decades.

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