News Release

New Cleveland Clinic-developed screening tool can assess cognition issues in older adults

Findings published in Journal of Alzheimer’s Disease

Peer-Reviewed Publication

Cleveland Clinic

Cleveland: A self-administered screening tool, developed by Cleveland Clinic researchers, can effectively and efficiently assess cognition issues in older adults.


A new study found that the simple test taken on a tablet computer before an annual physical is conducive to use in a primary care setting for detecting mild cognitive impairment, early Alzheimer’s disease, and other related dementias. Results were published in Journal of Alzheimer’s Disease.


About 15% to 20% of the population in the United States has mild cognitive impairment, a significant risk factor for Alzheimer’s disease. A substantial proportion of patients with mild cognitive impairment and early Alzheimer’s disease are underdiagnosed and underreported, with diagnosis typically occurring late in the disease course.


“The goal of this low-cost screening is to incorporate testing into an annual physical for older adults and make it as routine as checking your blood pressure and weight,” said Stephen Rao, Ph.D., lead author of the study and director of the Schey Center for Cognitive Neuroimaging at Cleveland Clinic. “As the population ages and the incidence of Alzheimer’s and other dementias increases rapidly, it is critical that we find new ways to identify the disease early.”


Currently, there are no definitive screening tests for mild cognitive impairment and early Alzheimer’s for healthy older adults. Existing tests, such as MRI, genetic testing and PET scans, are either non-definitive or too costly to give every patient. Dr. Rao and Cleveland Clinic colleagues developed the 10-minute self-administered brain health assessment. The Cleveland Clinic Cognitive Battery (C3B) assesses memory and thinking skills, to provide efficient screening of cognitive impairment of adults age 65 and older during their Medicare annual wellness visits.


The research team validated the tool in a series of studies, starting with an initial assessment of 428 participants, ages 18-89, who were doing well cognitively to provide norms for aiding clinical interpretation.


This was followed by integrating the tool into a primary care clinic, in which patients took the computerized test in the waiting room prior to seeing their doctor. Greater than 95 percent of older patients over age 65 were able to complete the unsupervised computerized tests and a survey indicated a high degree of satisfaction in taking the screening tool. 


The researchers then assessed the tool in 30 older adults with diagnosed mild cognitive impairment compared with a cohort of 30 older adults without the condition. The tool identified 90% of patients with mild cognitive impairment, whereas a common screening tool currently used in primary care clinical practice identified only 45%.


“We demonstrated that the C3B tool was able to distinguish mild cognitive impairment patients from demographically matched people who did not have the condition,” said Dr. Rao. “Overall this study showed that this simple screening can be effectively used in a busy primary care setting for detecting mild cognitive impairment.”


Studying people before they have any symptoms of dementia is important because the disease can begin in the brain 10 to 20 years before diagnosis. If the disease can be detected earlier before significant brain damage occurs, patients can potentially modify their risk.


“Many risk factors such as physical inactivity, depression, obesity and smoking are amenable for primary care intervention that could delay or prevent dementia if detected in the earliest stage of the disease,” said Dr. Rao.


“If we can slow down the disease to delay onset by five years we can cut the number of people diagnosed by half. If we can delay by 10 years, we can practically eliminate the disease and improve length and quality of life. Disease-modifying drugs and lifestyle interventions, like physical activity, can delay the diagnosis of dementia if implemented at the earliest stage of the disease.”


Dr. Rao’s team is currently preparing for a large multisite study to better define test result thresholds for cognitive dysfunction and to expand diversity of the test population. Patients — both those who score well and those who score poorly on the C3B — will be randomly selected to undergo MRI scanning, laboratory tests and extensive neurological examination.


Disclosures: Dr. Rao has co-authored intellectual property around the C3B software for which he has received royalties from Cleveland Clinic.


About Cleveland Clinic

Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. U.S. News & World Report consistently names Cleveland Clinic as one of the nation’s best hospitals in its annual “America’s Best Hospitals” survey. Among Cleveland Clinic’s 72,500 employees worldwide are more than 5,050 salaried physicians and researchers, and 17,800 registered nurses and advanced practice providers, representing 140 medical specialties and subspecialties. Cleveland Clinic is a 6,500-bed health system that includes a 173-acre main campus near downtown Cleveland, 22 hospitals, more than 220 outpatient facilities, including locations in northeast Ohio; southeast Florida; Las Vegas, Nevada; Toronto, Canada; Abu Dhabi, UAE; and London, England. In 2021, there were 10.2 million total outpatient visits, 304,000 hospital admissions and observations, and 259,000 surgical cases throughout Cleveland Clinic’s health system. Patients came for treatment from every state and 185 countries. Visit us at Follow us at News and resources available at

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