https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/13/issue/2

Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.

APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.

Articles of interest in this issue include:

 

Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism by Changpei Gan, Jing Wang, Alejandra Martínez-Chávez et al. (https://doi.org/10.1016/j.apsb.2022.10.017). Carboxylesterase 1 enzymes impact in vivo pharmacokinetics of anticancer prodrugs irinotecan and capecitabine. Lipid homeostasis in adipose tissues is also regulated by CES1, partly through triglyceride mobilization in liver.

 

SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR by Shuang Cui, Huijian Hu, An Chen et al. (https://doi.org/10.1016/j.apsb.2022.08.019). Acetylation drives and orchestrates nucleocytoplasmic shuttling and cytosolic degradation of FXR, which accounts for limited hepatoprotective benefits of FXR agonists. SIRT1 activation synergizes with FXR agonists in hepatoprotection.

 

A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis by Dan Wang, Bochuan Deng, Lu Cheng et al. (https://doi.org/10.1016/j.apsb.2022.09.001). Novel peptide DR3penA with high stability and low toxicity effectively attenuates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis.

 

Other articles include:

 

Review Articles

Expression and functions of transient receptor potential channels in liver diseases

Wenhui Wang, Pengyu Liu, Yalin Zhang, Li Yan, ... Ye Yu

Developmental toxicity and programming alterations of multiple organs in offspring induced by medication during pregnancy

Zhengjie Lu, Yu Guo, Dan Xu, Hao Xiao, ... Hui Wang

Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine

Yeuan Ting Lee, Yi Jer Tan, Chern Ein Oon

Peptide–drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope?

Chen Fu, Lifeng Yu, Yuxi Miao, Xinli Liu, ... Minjie Wei

Medical micro- and nanomotors in the body

Huaan Li, Fei Peng, Xiaohui Yan, Chun Mao, ... Yingfeng Tu

 

Original Articles

Synergistic activation of AMPK by AdipoR1/2 agonist and inhibitor of EDPs–EBP interaction recover NAFLD through enhancing mitochondrial function in mice

Nazi Song, Hongjiao Xu, Shuohan Wu, Suijia Luo, ... Xianxing Jiang

Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis

Yujun Zhou, Jingshu Tang, Jiaqi Lan, Yong Zhang, ... Ying Peng

Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in NPM1-mutated acute myeloid leukemia

Yin Feng, Yefan Han, Anni Hu, Yi Qu, ... Li He

Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1^highCD11b⁺ cells elimination in hepatocellular carcinoma

Jizhou Tan, Ting Liu, Wenzhe Fan, Jialiang Wei, ... Jiaping Li

The role of CYP1A1/2 in cholesterol ester accumulation provides a new perspective for the treatment of hypercholesterolemia

Jian Lu, Xuyang Shang, Bingyi Yao, Dongyi Sun, ... Xin Wang

Impeding the combination of astrocytic ASCT2 and NLRP3 by talniflumate alleviates neuroinflammation in experimental models of Parkinson's disease

Yang Liu, Ting Liu, Yuanzhang Zhou, Wenjie Li, ... Ming Lu

Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases

Haowen Xu, Jiahao Chen, Pan Chen, Weifeng Li, ... Guang Liang

PAFR/Stat3 axis maintains the symbiotic ecosystem between tumor and stroma to facilitate tumor malignancy

Di Zhao, Jing Zhang, Lingyuan Zhang, Qingnan Wu, ... Qimin Zhan

Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators

Siyuan Tang, Miguel Garzon Sanz, Oliver Smith, Andreas Krämer, ... Sam Butterworth

Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia

Zhifu Xie, Mei Zhang, Qian Song, Long Cheng, ... Fajun Nan

(+)/(−)-Yanhusamides A−C, three pairs of unprecedented benzylisoquinoline-pyrrole hetero-dimeric alkaloid enantiomers from Corydalis yanhusuo

Lingyan Wang, Guiyang Xia, Huan Xia, Xiaohong Wei, ... Sheng Lin

Insights into the biosynthesis of septacidin l-heptosamine moiety unveils a VOC family sugar epimerase

Meng Chen, Zhengyan Guo, Jinyuan Sun, Wei Tang, ... Yihua Chen

A metabolic intervention strategy to break evolutionary adaptability of tumor for reinforced immunotherapy

Qianhua Feng, Yutong Hao, Shuaiqi Yang, Xiaomin Yuan, ... Lei Wang

Reprogrammed siTNFα/neutrophil cytopharmaceuticals targeting inflamed joints for rheumatoid arthritis therapy

Yijun Chen, Kaiming Li, Mengying Jiao, Yingshuang Huang, ... Can Zhang

A tactical nanomissile mobilizing antitumor immunity enables neoadjuvant chemo-immunotherapy to minimize postsurgical tumor metastasis and recurrence

Tao He, Mingxing Hu, Shunyao Zhu, Meiling Shen, ... Changyang Gong

Salmonella-mediated blood‒brain barrier penetration, tumor homing and tumor microenvironment regulation for enhanced chemo/bacterial glioma therapy

Ze Mi, Qing Yao, Yan Qi, Jinhai Zheng, ... Pengfei Rong

Nanopolyphenol rejuvenates microglial surveillance of multiple misfolded proteins through metabolic reprogramming

Dayuan Wang, Xiao Gu, Xinyi Ma, Jun Chen, ... Hongzhuan Chen

Precise assembly of inside-out cell membrane camouflaged nanoparticles via bioorthogonal reactions for improving drug leads capturing

Xiaolin Zhang, Xueyan Zhen, Yixuan Yang, Quan Feng, ... Xiaoyu Xie

Iron-based and BRD₄-downregulated strategy for amplified ferroptosis based on pH-sensitive/NIR-II-boosted nano-matchbox

Lujing Geng, Tong Lu, Huaqing Jing, Yue Zhou, ... Nan Li

Photosensitive pro-drug nanoassemblies harboring a chemotherapeutic dormancy function potentiates cancer immunotherapy

Jianjun Cheng, Haitian Zhao, Bin Li, Hua Zhang, ... Xin Yang

 

 

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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.

For more information please visit https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/

Editorial Board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board

 

APSB is available on ScienceDirect (https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b).

 

Submissions to APSB may be made using Editorial Manager® (https://www.editorialmanager.com/apsb/default.aspx).

 

CiteScore: 15.9

Impact Factor: 14.907

JIF without self-citation: 13.885

 

ISSN 2211-3835

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