https://doi.org/10.1016/j.apsb.2022.08.006
This new article publication from Acta Pharmaceutica Sinica B, discusses how Anti-PD-L1 antibody enhances the curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1highCD11b+ cells elimination in hepatocellular carcinoma.
Cryoablation (CRA) and microwave ablation (MWA) are two main local treatments for hepatocellular carcinoma (HCC). However, which one is more curative and suitable for combining with immunotherapy is still controversial. Herein, CRA induced higher tumoral PD-L1 expression and more T cells infiltration, but less PD-L1highCD11b+ myeloid cells infiltration than MWA in HCC. Furthermore, CRA had better curative effect than MWA for anti-PD-L1 combination therapy in mouse models. Mechanistically, anti-PD-L1 antibody facilitated infiltration of CD8+ T cells by enhancing the secretion of CXCL9 from cDC1 cells after CRA therapy. On the other hand, anti-PD-L1 antibody promoted the infiltration of NK cells to eliminate PD-L1highCD11b+ myeloid cells by antibody-dependent cell-mediated cytotoxicity (ADCC) effect after CRA therapy. Both aspects relieved the immunosuppressive microenvironment after CRA therapy. Notably, the wild-type PD-L1 Avelumab (Bavencio), compared to the mutant PD-L1 atezolizumab (Tecentriq), was better at inducing the ADCC effect to target PD-L1highCD11b+ myeloid cells. Collectively, this study uncovers the novel insights that CRA showed superior curative effect than MWA in combining with anti-PD-L1 antibody by strengthening CTL/NK cell immune responses, which provided a strong rationale for combining CRA and PD-L1 blockade in the clinical treatment for HCC.
Keywords: Hepatocellular carcinoma, Immunotherapy, Cryoablation, Microwave ablation, CXCL9, NK cells, Antibody-dependent cell-mediated cytotoxicity, Immunosuppressive microenvironment
Graphical Abstract: available at https://ars.els-cdn.com/content/image/1-s2.0-S2211383522003410-ga1_lrg.jpg
Anti-PD-L1 antibody plays a key role in improving curative effect of cryoablation of HCC via blocking PD-L1. It can enhance antitumor activity of CTL/NK cells and eliminating PD-L1highCD11b+ cells by antibody-dependent cell-mediated cytotoxicity (ADCC) effect.
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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.
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CiteScore: 15.9
Impact Factor: 14.907
JIF without self-citation: 13.885
ISSN 2211-3835
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Article reference: Jizhou Tan, Ting Liu, Wenzhe Fan, Jialiang Wei, Bowen Zhu, Yafang Liu, Lingwei Liu, Xiaokai Zhang, Songling Chen, Haibiao Lin, Yuanqing Zhang, Jiaping Li, Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1highCD11b+ cells elimination in hepatocellular carcinoma, Acta Pharmaceutica Sinica B, Volume 13, Issue 2, 2023, Pages 632-647, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2022.08.006