News Release

Smells influence metabolism and ageing in mice - research

Peer-Reviewed Publication

University of Otago

Exposure to female odours and pheromones causes weight loss and extend the life spans of mice, which may have implications for humans, University of Otago researchers have found.

Lead researcher Dr Michael Garratt, of the Department of Anatomy, says while it was already known that sensory cues in humans and animals influence the release of sex hormones, this study shows that these cues could have more wide-spread physiological effects on metabolism and ageing.

“Our studies show that female odours slow the sexual development of female mice, but consequently extends their lifespan. And we also show that the smell of females can increase male mouse energy expenditure, which subsequently influences their body weight and body fat levels,” he says.

Newborn mice were exposed to odours from adult females until they were 60 days old. Those females exposed to the odours reached sexual maturity later and lived an average 8 per cent  longer than those not exposed.

There was no effect of male odours on female mouse lifespan, or changes in lifespan in males in response to odours from either sex.

“As far as we know, this is the first observation that lifespan can be increased in a mammal by olfactory signals, or indeed secreted factors found in soiled bedding and urine,” Dr Garratt says.

“More generally, the work hints that sensory cues from our social environment can cause changes to our physiology and development, which may have long-term effects that extend to influence how we age.”

While male mice did not directly benefit in terms of longevity from female odours during development, when they are exposed to female odours as adults, their weight and metabolism was substantially affected, he says.

“We have found that exposing male mice to female odours increases their energy expenditure for several hours after exposure.

“These effects are sufficient to induce weight loss and protect against males getting very fat when they are fed a diet that has an excess of energy.”

Regardless of the cause for improved metabolic health and longevity with female pheromones, the results suggest olfactory cues from other individuals may induce more widespread changes across the body.

“We would now like to understand how information received by the olfactory system is capable of inducing widespread effects. It is also possible that exposing male mice to female odours when they are adults may influence their lifespans and that’s a question we are currently pursuing,” Dr Garratt says.

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