A new perspective published in the journal Nature Chemical Biology uncovers a previously unknown biochemical recycling process in animals. The authors review a flurry of recent papers demonstrating that animals extensively recycle biochemical waste to produce novel chemicals that play key roles in biology, from regulating behavior to development and aging.
These studies show that the genes previously thought to code for carboxylesterases, enzymes that hydrolyze esters, actually play a pivotal role in assembling a wide range of new metabolites from building blocks generally considered “cellular waste.” Surprisingly, the so-called carboxylesterases were found to contribute to the formation of esters and amide bonds, a function opposite to that predicted by computational algorithms.
“This discovery reveals that our understanding of biochemistry remains largely incomplete,” says the perspective’s lead author, Frank Schroeder, a professor at Boyce Thompson Institute (BTI). “This research has the potential to revolutionize our understanding of how animals, including humans, function.”
Recent investigations indicate that animals and humans may produce over 100,000 distinct chemicals, most of which have not been investigated. This unknown structure space is a treasure trove of chemicals, which may hold the key to understanding many biological processes. One major challenge to understanding how these metabolites contribute to survival is that the enzymes that produce them are also unknown.
“The discovery of this biochemical recycling mechanism opens up exciting new avenues for future research, with the potential to dramatically accelerate the structural and functional annotation of unknown metabolites,” says Chester Wrobel, a graduate student in the Schroeder lab and co-author of the perspective.
About the Boyce Thompson Institute (BTI)
Opened in 1924, Boyce Thompson Institute is a premier life sciences research institution located in Ithaca, New York. BTI scientists conduct investigations into fundamental plant and life sciences research with the goals of increasing food security, improving environmental sustainability in agriculture, and making basic discoveries that will enhance human health. Throughout this work, BTI is committed to inspiring and educating students and to providing advanced training for the next generation of scientists. BTI is an independent nonprofit research institute that is also affiliated with with Cornell University. For more information, please visit BTIscience.org.
Nature Chemical Biology
Repurposing degradation pathways for modular metabolite biosynthesis in nematodes
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