News Release

Evaluation of Waning of SARS-CoV-2 Vaccine–Induced Immunity

JAMA Network Open

Peer-Reviewed Publication

JAMA Network

About The Study: The findings of this systematic review and meta-analysis of secondary data from 40 studies suggest that the effectiveness of COVID-19 vaccines against laboratory-confirmed Omicron or Delta infection and symptomatic disease rapidly wanes over time after the primary vaccination cycle and booster dose. These results can inform the design of appropriate targets and timing for future vaccination programs. 

Authors: Piero Poletti, Ph.D., of the Bruno Kessler Foundation in Trento, Italy, is the corresponding author. 

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ 

(doi:10.1001/jamanetworkopen.2023.10650)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.


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