News Release

Importance of Wolbachia-mediated biocontrol to reduce dengue in Bangladesh and other dengue-endemic developing countries

Peer-Reviewed Publication

Compuscript Ltd

Mosquito-borne diseases, particularly dengue and chikungunya have become global threats, infecting millions of people worldwide, including developing countries of Southeast Asia and Latin America. Bangladesh, like many other developing countries, is experiencing frequent dengue outbreaks. This article, therefore, critically discusses the current status of dengue disease, vector control approaches, and the need for Wolbachia-mediated intervention in Bangladesh and other dengue-endemic developing countries.

Relevant literature was searched from major databases and search engines such as PubMed, BanglaJol, World Health Organization (WHO)/European Centre for Disease Prevention and Control (ECDC) and Google Scholar. Considering the selection criteria, search strategies finally involved 55 related literature for further investigation. Findings showed that current vector control strategies could not render protection for an extended period, and the disease burden of arboviruses is increasing. The impoverished outbreak preparedness, urbanization, climate change, and less efficacy of existing control methods have made people susceptible to vector-borne diseases. Hence, Wolbachia, a naturally occurring endosymbiont of many mosquito species that can potentially limit virus transmission through several host genetic alterations, would be a potential alternative for dengue prevention.

The authors also critically discuss the challenges and prospects of Wolbachia-based dengue control in developing countries. The evidence supporting the efficacy and safety of this intervention and its mechanism have also been elucidated. Empirical evidence suggests that this introgression method could be an eco-friendly and long-lasting dengue control method. This review helps policymakers and health experts devise a scheme of Wolbachia-based dengue control that can control mosquito-borne diseases, particularly dengue in Bangladesh and other developing countries.



  • Approximately 3.9 billion people are prone to the dengue virus.
  • Current vector control strategies have been found less effective and cannot render protection for a long period.
  • Wolbachia-mediated biocontrol could be a promising alternative for dengue prevention.
  • Wolbachia grow naturally in 40%–60% of all insect species.
  • This dengue-control intervention is eco-friendly and confers long-term control.


Keywords: Wolbachia-based biocontrol, Mosquitoes-borne diseases, Dengue, Biological control, Developing countries


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CiteScore: 4.8

ISSN 2590-0536


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Abdullah Al Noman, Debashish Das, Zinnatun Nesa, Md. Tariquzzaman, Fariha Sharzana, Md. Rakibul Hasan, Baizid Khoorshid Riaz, Golam Sharower, Mohammad Meshbahur Rahman, Importance of Wolbachia-mediated biocontrol to reduce dengue in Bangladesh and other dengue-endemic developing countries, Biosafety and Health, Volume 5, Issue 2, 2023, Pages 69-77, ISSN 2590-0536,

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