Smoke from the massive wildfires still burning in northern Canada has cast a pall over much of North America this summer, leading to health concerns for older people and those with chronic respiratory conditions.
But a new paper published in the Journal of Neuroinflammation by University of New Mexico Health Sciences scientists gives new cause for alarm, finding that wildfire smoke can trigger inflammation in the brain that persists for a month or more.
Worse, the inflammatory process affects the hippocampus – the brain region associated with learning and memory – altering neurotransmitters and signaling molecules, said the paper’s senior author, Matthew Campen, PhD, Regents’ professor in the College of Pharmacy and co-director of the UNM Clinical & Translational Science Center.
The research was led by David Scieszka, PhD, a postdoctoral student in Campen’s laboratory who exposed rodents to wood smoke every other day for two weeks. “We were trying to figure out if the stuff we saw in the wild could at least be partially figured out in the lab,” he said.
The team identified both pro- and anti-inflammatory responses as tiny particles from the smoke entered the circulation from the lungs and crossed the blood-brain barrier, a layer of tightly packed cells lining blood vessels in the brain.
“We were able to measure the inflammatory response amplitude and time frames,” Scieszka said. “We expected it to be a lot shorter. Some of it progressed out to 28 days and we didn’t see a complete resolution, and that was very scary to us.”
The blood-brain barrier cells had had largely adapted to the smoke exposure by Day 14, but the immune cells in the brain remained abnormally activated, he said.
Campen said the findings are concerning given how many people are now regularly exposed to wildfire smoke.
“Neuroinflammation is the seed for all sorts of bad things in the brain, including dementia, Alzheimer’s disease – the buildup of the plaques – but also alterations in neurodevelopment in early life and mood disorders throughout life,” he said. “If you’re a firefighter, or if you’re just a citizen in a community that has had some of these dramatic smoke exposures, you could be having neurocognitive or mood disorders weeks or months or weeks after the event.”
With heavy concentrations of wildfire smoke, people should remain inside if they can, Campen said. “Houses have varying penetrance of particulates. If you’ve got an evaporative cooler, you’re just being exposed to the outdoor air, but a lot of houses will be much more protective.” N-95 masks offer protection to those who venture outside, he added.
The human body seems capable of adapting to chronic particulate exposure to an extent, Campen said. But periodic exposures pose a problem because they cause a surge in inflammatory activity, and ill effects appear more related to the fluctuations, rather than the baseline levels of pollutants.
“Part of what makes this so unique and worrisome is the intermittent nature of it,” he said. “We have rural communities that are otherwise enjoying clean beautiful air, especially in the Rocky Mountain region, and then all of a sudden they have suffocating levels of pollutants and it’s gone a week later. It’s a real hit to a naïve system.”
Journal of Neuroinflammation
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David Scieszka, Yan Jin, Shahani Noor, Ed Barr, Marcus Garcia, Jessica Begay, Guy Herbert, Russell P. Hunter, Kiran Bhaskar, Rahul Kumar, Rama Gullapalli, Alicia Bolt, Mark A. McCormick, Barry Bleske, Haiwei Gu & Matthew J. Campen Journal of Neuroinflammation volume 20, Article number: 192 (2023) Cite this article 299 Accesses 11 Altmetric Metrics details Abstract Smoke from wildland fires has been shown to produce neuroinflammation in preclinical models, characterized b
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The authors state that they have no competing interests.