High concentrations of free fatty acid (FFA) in ketotic dairy cows activate endoplasmic reticulum (ER) stress pathways, contributing to mammary epithelial cell apoptosis and reduced milk yield. The study sets the stage for in vivo trials to validate ER stress inhibitors like Tauroursodeoxycholate (TUDCA) as practical solutions for managing ketosis and enhancing dairy cows health.

Researchers have established a comprehensive public dataset, GlycoHBF, which provides a detailed map of proteins and their glycosylation (N-glycosylation) across 15 types of human body fluids. Using standardized processing and advanced mass spectrometry, the study reveals significant molecular heterogeneity among fluids like plasma, urine, saliva, tears, and cerebrospinal fluid. This work provides a rigorous analytical framework and a baseline reference that will accelerate the discovery of liquid biopsy biomarkers for diseases including cancer and neurological disorders.

In a review, researchers summarize tribovoltaic nanogenerators for harvesting human motion energy. These systems not only produce stable direct-current electricity with high power density but also enable self-powered sensing for real-time motion and physiological monitoring. Advanced materials, interface engineering, and textile designs further enhance flexibility, durability, and performance for wearable applications.