Liver organoids, three-dimensional structures derived from stem cells or hepatic progenitors, have emerged as a transformative technology. Unlike traditional two-dimensional cultures or animal models, organoids faithfully recapitulate the complex architecture and functionality of native liver tissue. This review summarizes recent advancements in liver organoid technology, detailing their development, classification, and key applications.

A recent review published in Science Bulletin outlines the evolving landscape of metabolic dysfunction‑associated steatotic liver disease (MASLD), emphasizing a suite of non-invasive genetic, metabolic and microbial markers that improve disease detection and prognosis, and summarising the clinical significance of the recent FDA‑approved drugs, resmetirom and semaglutide, along with a robust pipeline of late‑stage therapeutics. Crucially, the review addresses the substantial hurdles to clinical translation in newly developed biomarkers, including validation, standardization, and cost, and proposes a roadmap for translating these scientific advances into effective, personalized patient care.

For the first time, researchers have shown through simulation that a novel X-shaped sleeper enhances trackbed stability under impact loading by redistributing loads through a denser, more uniform network of force chains, reducing stress concentrations and improving energy dissipation.

Don't rush into braces if you have a jaw and crooked teeth issue. This study reveals that while proper orthodontics can help a healthy jaw joint, incorrect treatment can worsen disc displacement and even cause bone loss. Simply using splints often leads to high relapse rates. The experts recommend a "Sequential Strategy": first surgically reposition the disc, then perform orthodontic treatment. This approach aims to fix the joint first to ensure stable, long-term results for both your bite and facial appearance.

Oral nanomaterial formulations enhance drug stability, solubility, mucosal penetration and targeted delivery for gastrointestinal therapy. This review compares metallic and non-metallic nanomaterials and highlights the strong clinical translation potential of non-metallic systems, especially selenium nanoparticles (SeNPs).