Researchers tested pyrvinium pamoate against Merkel cell carcinoma with positive results.

New research shows that enhancing norepinephrine signaling in microglia reduces inflammation and toxic amyloid buildup in Alzheimer’s models. Loss of this pathway worsened plaques and neurodegeneration, findings that suggest that early targeting therapies could slow disease progression.

How do we learn new things? Neurobiologists using cutting-edge visualization techniques have revealed how changes across our synapses and neurons unfold. The findings depict how information is processed in our brain’s circuitry, offering insights for neurological disorders and brain-like AI systems.

Scientists at Duke University School of Medicine, University of Texas Health Science Center at San Antonio could reshape cancer treatment by helping powerful drugs work better in the body. By exploiting a surface protein called CD36 that helps pull substances into cells. dramatically improves the uptake of a promising class of cancer-fighting drugs called PROTACs, New drug design deliveries up to 22 times more of he drug inside cancer cells, and tumor suppression in mice, according to a study in Cell.