AI identifies key gene sets that cause complex diseases
Peer-Reviewed Publication
Updates every hour. Last Updated: 16-Jun-2025 06:09 ET (16-Jun-2025 10:09 GMT/UTC)
Complex illnesses are not caused by one gene but groups of genes. The number of gene combinations is too enormous to analyze comprehensively. New AI model focuses on gene expression changes to identify key genes and their collective influence on disease.
Researchers from the University of Michigan Rogel Cancer Center developed a new mouse model that shows CDK12 acts as a tumor suppressor to drive high-grade serous carcinoma arising in the mouse oviduct – the equivalent of human fallopian tube. A promising degrader targeting CDK12 and a related gene, CDK13, can destroy these tumors.
As recommendations suggest extending hormone-based breast cancer treatment to 10 years for some patients, a new study sheds light on whether patients are opting for it. In a study of 591 women with early stage breast cancer who completed five years of endocrine therapy, 47% decided to continue the treatment.