Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes
Peer-Reviewed Publication
Updates every hour. Last Updated: 1-May-2025 11:08 ET (1-May-2025 15:08 GMT/UTC)
Researchers from Johns Hopkins University have identified three subtypes of senescent skin cells with distinct shapes, biomarkers, and functions—an advance that could equip scientists with the ability to target and kill the harmful types while leaving the helpful ones intact.
Scientists at Northwestern University and University of California San Diego have developed a new, potent injectable therapy that can protect the heart from damage after a heart attack. After showing success in cell culture, the scientists tested their new therapy in a rat model of heart attack. Following a single, low-dose intravenous injection, the animals experienced decreased inflammation and cell death along with improved cardiac function and increased growth of new blood vessels.
Historically, small molecule drugs have been precisely designed down to the atomic scale. Considering their relatively large complex structures, nanomedicines have lagged behind. Researchers argue this precise control should be applied to optimize new nanomedicines. "By controlling structure, we can create the most potent medicines with the lowest chance of adverse side effects," researcher says.