Yeasts are physically hard to distinguish, and it is easy to think they are all the same. Metabolically, genetically and biochemically, however, yeasts are highly diverse. So far industry has only harnessed a fraction of the diversity available for biotechnological applications, including biofuel production. In the Proceedings of the National Academy of Sciences, a team led by DOE Joint Genome Institute researchers aims to help boost the use of a wider range of yeasts.