A plant's immune system can distinguish between friends and foes among these microbes, and upon detecting pathogens, can produce regulatory chemicals called phytohormones to activate a defensive response. In a study published online July 16, 2015, in Science Express, a team including scientists from the US Department of Energy Joint Genome Institute looked at roles of three phytohormones in controlling the composition of the root microbiome in the model plant Arabidopsis thaliana.