The structure of the DNA-slicing protein FEN1, an essential player in human DNA replication, has been solved by an international team of life scientists led by researchers at Lawrence Berkeley National Laboratory and the Scripps Research Institute. FEN1 cuts the "flaps" leftover when new fragments of DNA are assembled during replication and also plays a role in DNA repair. Its protein structure reveals the surprising mechanism behind FEN1's speed, accuracy, and versatility.