Cellulosic ethanol -- fuel derived from woody plants and waste biomass -- has the potential to become an affordable, renewable transportation fuel that rivals gasoline, but lignin, one of the most ubiquitous components of the plant cell wall, gets in the way. To better understand exactly how lignin persists, a team based at Oak Ridge National Laboratory created one of the largest biomolecular simulations to date -- a 23.7-million atom system representing pretreated biomass (cellulose and lignin) in the presence of enzymes.