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Protein prediction tool has good prospects

DOE/Oak Ridge National Laboratory

ORNL ranks high in its ability to computationally predict protein structures. The next step is to speed up predictions to facilitate the search for effective drugs.

Surprises in the mouse genome

DOE/Oak Ridge National Laboratory

In the live organism, not all mouse and human genes have predictable functions, and proteins with similar structures can have different functions.

Human genome analyzed using supercomputer

DOE/Oak Ridge National Laboratory

A computational analysis of the human genome by ORNL and UT researchers provides insights into what our genes do.

Rapid genetic disease screening possible using laser mass spectrometry

DOE/Oak Ridge National Laboratory

Laser desorption mass spectrometry is emerging as a new tool for screening populations for various genetic diseases

Microbe probe

DOE/Oak Ridge National Laboratory

ORNL researchers are using gene chips, mass spectrometry, and computational analysis to understand what microbe genes do.

Protein identification by mass spectrometry

DOE/Oak Ridge National Laboratory

ORNL researchers are improving mass spectrometry tools to speed up protein identification and to screen for disease-causing proteins and bacteria.

The mouse house: From old to new

DOE/Oak Ridge National Laboratory

While some ORNL mice are allowed to grow old for studies of aging, mutant mouse embryos are being frozen, awaiting birth after the new Mouse House is built.

SNS and biological research

DOE/Oak Ridge National Laboratory

Three world-class biological instruments are being designed for the Spallation Neutron Source. They will help biologists determine the atomic-level structure of proteins and other signaling compounds that allow cells to communicate and coordinate activities across an organism. The research could lead to safer, more effective drugs.

Lab on a chip used for protein studies

DOE/Oak Ridge National Laboratory

ORNL's lab on a chip is being used commercially to identify proteins and shows promise for drug discovery and disease screening.

Genes and proteins

DOE/Oak Ridge National Laboratory

Consider a living cell, the fundamental unit of life. Each human cell contains the entire human genome—some 35,000 genes. But only some genes are expressed within a specific cell, resulting in the production of specific proteins. The genes that turn on in a liver cell, for example, are different from the genes that are expressed in a brain cell.