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18-Jun-2001
Gene chip engineers
DOE/Oak Ridge National Laboratory
At ORNL, microarrays are being made faster and cheaper to study gene expression in cells
from mice, fish, and other organisms.
18-Jun-2001
MicroCAT 'sees' hidden mouse defects
DOE/Oak Ridge National Laboratory
ORNL's X-ray computed tomography system allows internal defects and organ changes in
small animals to be mapped.
18-Jun-2001
Obesity-related gene in mouse discovered at ORNL
DOE/Oak Ridge National Laboratory
Some mice born at ORNL have grown dangerously fat, even though they have been on
a low-fat diet since birth. Although they do not appear overweight, these mice have a
mutated gene that plays a strong role in causing obesity in the form of internal fat
deposits that are hazardous to their health.
18-Jun-2001
Curing cancer in mice
DOE/Oak Ridge National Laboratory
ORNL researchers have shown that a radioisotope-bearing antibody can target the blood
vessels of lung tumors in mice, destroying the tumors.
18-Jun-2001
Complex biological systems in mice
DOE/Oak Ridge National Laboratory
Using genetic engineering, gene microarrays, and computational technologies, ORNL
researchers are deciphering genetic variations in the skin that lead to increased risk of
disease from environmental factors.
18-Jun-2001
Search for signs of inflammatory disease
DOE/Oak Ridge National Laboratory
You fall on your shoulder and tear some cartilage, causing bone to rub against bone.
Your shoulder becomes inflamed and begins to hurt because cytokine, a small signal
protein secreted by your immune system, has recruited white blood cells to clean up the
damage.
18-Jun-2001
Mouse models for the human disease of chronic hereditary tyrosinemia
DOE/Oak Ridge National Laboratory
When a section of mouse chromosome 7 containing the coat color c gene is deleted by
exposing mice to radiation, "albino" mice are born with a white, hairless coat.
23-Jan-2001
Story tips from the Department of Energy's Oak Ridge National Laboratory, January 2001
DOE/Oak Ridge National LaboratoryPeer-Reviewed Publication
HEALTH-Better CPR a heartbeat away? TRANSPORTATION-Safer
Skies. ENVIRONMENT-Ocean's biology under spotlight. VEHICLE
SAFETY-Driving dangerously.
1-Jan-2001
Systems biology
DOE/Oak Ridge National Laboratory
ORNL scientists are conducting research in functional genomics—the study of genomes to
determine the biological function of all the genes and their products—and proteomics—the
study of the full set of proteins encoded by a genome.