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X-rays size up protein structure at the 'heart' of COVID-19 virus

DOE/Oak Ridge National Laboratory
Peer-Reviewed Publication

Researchers have performed the first room temperature X-ray measurements on the SARS-CoV-2 main protease -- the enzyme that enables the virus to reproduce. It marks an important first step in the ultimate goal of building a comprehensive 3D model of the enzymatic protein that will be used to advance supercomputing simulations aimed at finding drug inhibitors to block the virus's replication mechanism and help end the COVID-19 pandemic.

Journal: Nature Communications
Funder: NIH/National Institute of Allergy and Infectious Diseases, Laboratory Directed Research and Development program, Oak Ridge National Laboratory, National Science Foundation

ExOne licenses ORNL method to 3D print components for refined neutron scattering

DOE/Oak Ridge National Laboratory
Business Announcement

The Department of Energy's Oak Ridge National Laboratory has licensed a novel method to 3D print components used in neutron instruments for scientific research to the ExOne Company, a leading maker of binder jet 3D printing technology.

Funder: Department of Energy's Office of Science

ORNL launches rapid access licensing program to speed up COVID-19 solutions

DOE/Oak Ridge National Laboratory
Business Announcement

Oak Ridge National Laboratory has launched a program designed to accelerate deployment of innovations that may help fight the COVID-19 pandemic.

Molten salt solutions may supply scientists with new insights into nuclear energy

DOE/Oak Ridge National Laboratory

Molten salt reactors could become a cornerstone of nuclear energy. Researchers at MIT are using neutron scattering at ORNL to better understand how salt solutions behave in nuclear environments. Modeling those behaviors could lead to significant gains in commercializing molten salt reactors for carbon-free power production.

History of insightful HIV research inspires neutron scattering approach to studying COVID-19

DOE/Oak Ridge National Laboratory

What began as novel investigations into HIV, abruptly pivoted to the novel coronavirus as it began to spread across the globe. Now, ORNL researchers are using neutrons to learn more about the SARS-CoV-2 protease--a protein enzyme that enables the virus to replicate within the human body. Insights on the protein structure and its behaviors will be used to create more accurate models for simulations in aims of finding drug inhibitors to block the virus's ability to reproduce.

Oak Ridge National Laboratory welcomes 6 new research fellows to Innovation Crossroads

DOE/Oak Ridge National Laboratory
Grant and Award Announcement

Oak Ridge National Laboratory welcomed six technology innovators to join the fourth cohort of Innovation Crossroads, the Southeast's only entrepreneurial research and development program based at a US Department of Energy national laboratory.

Crystalline 'nanobrush' clears way to advanced energy and information tech

DOE/Oak Ridge National Laboratory
Peer-Reviewed Publication

A team led by the Department of Energy's Oak Ridge National Laboratory synthesized a tiny structure with high surface area and discovered how its unique architecture drives ions across interfaces to transport energy or information. Their 'nanobrush' contains bristles made of alternating crystal sheets with vertically aligned interfaces and plentiful pores. 'These are major technical accomplishments and may prove useful in advancing energy and information technologies,' said ORNL's Ho Nyung Lee, who led the study.

Journal: Nature Communications
Funder: US Department of Energy's Office of Science

VENUS construction on track for ORNL's newest neutron imaging instrument

DOE/Oak Ridge National Laboratory

Researchers and engineers at the Spallation Neutron Source are making progress on the construction of VENUS, the facility's newest neutron scattering instrument for studying materials in exciting new ways that are currently not possible for open research programs in the US.

Story tips: Shuffling atoms, thinning forests, fusion assembly and nuclear medicine

DOE/Oak Ridge National Laboratory
Peer-Reviewed Publication

ORNL Story Tips: Shuffling atoms, thinning forests, fusion assembly and nuclear medicine.

Journal: Nature
Funder: DOE/Biological and Environmental Research, DOE Isotope Program, DOE/US Department of Energy, DOE/Fusion Energy Sciences division, National Institutes of Health

As ORNL builds novel reactor, nuclear industry benefits from technology

DOE/Oak Ridge National Laboratory

Scientists at DOE's Manufacturing Demonstration Facility at Oak Ridge National Laboratory working on the Transformational Challenge Reactor, a microreactor built using 3D printing, find their work may revolutionize manufacturing in the nuclear industry -- and in other industries, too.

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