Propelling Biomaterial Innovations for Advanced Cell Therapy (IMAGE)
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Micro-CT evaluation and histomorphological observation of the in vivo bone regeneration in a rabbit femoral condyle defect model. The femoral condyle defects were implanted with P7L2DMA/50%nHA, P7L2DMA/50%nHAMA and P7L2DMA/50%nHAMA/BMP-2 scaffolds, and the rabbits with no scaffold implantation served as blank control. (A) 3D reconstructed micro-CT images of different groups showing the influences of different samples on the new bone formation after implantation for 4 and 8 weeks. The red color indicated the new bone tissues and green color represents the scaffolds. Quantitative statistic of (B) BV/TV and (C) BMD of the newly formed bone at week 4 and 8. BV/TV: bone volume/total volume; BMD: bone mineral density. (D) Representative images of Van Gieson's staining showing the osseointegration of scaffolds with the new bones. S represented implanted scaffolds and NB indicated new bone tissues. The red-stained areas indicated by the arrows refer to the ossein. (E) Quantitative analysis of the new bone area in the defects. Data are presented as mean ± SD and analyzed by one-way ANOVA (n = 6 for each group, *p < 0.05). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
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