Bmp9 knockout (KO) mouse model was successfully established. (IMAGE)
Caption
(A) Construction of the Bmp9-KO mice. (B) Relative expression of Bmp9 in the liver of 8-week-old wild-type (WT) littermates and Bmp9-KO mice by quantitative PCR in vitro (n ≥ 3). (C) Western blots of BMP9 and β-actin in the liver of 8-week-old WT littermates and Bmp9-KO mice (n = 6). (D) Immunohistochemical staining of BMP9 on sections of mandibular first molars from WT littermates and Bmp9-KO mice at 2 weeks and 4 weeks old (n = 7). The boxes shown are insets at a lower magnification. Am, ameloblasts; Od, odontoblasts; D, dentin. (E) Quantitative analysis of BMP9 expression. Scale bars = 200 μm.
Credit
Chang Liu, Hongyan Yuan, Jindie Huang, Shidian Ran, Xiaorui Wei, Xingrui Yan, Linyu Xue, Tong-Chuan He, Yuxin Zhang, Mengqin Gu, Si Wu, Fugui Zhang, Wenping Luo, Hongmei Zhang
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