Potential mechanism and validation of knocking out Bmp9 to inhibit cell proliferation and intercellular junctions. (IMAGE)

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Potential mechanism and validation of knocking out Bmp9 to inhibit cell proliferation and intercellular junctions.

Caption

(A) The volcano diagram portraying the gene expression profile between Bmp9 knockout (KO) mice and wild-type (WT) controls in the root apical papilla. Up-regulated genes were marked in red and down-regulated genes were marked in blue. (B) Top 10 pathways from the GO enrichment analysis. The top 10 items of biological processes (BP), the top 10 items of molecular functions (MF), and the top 10 items of cellular components (CC) were shown. (C) The top 25 items of KEGG pathway. (D) The relative mRNA levels of Ki67, Zo-1, and E-cadherin (n = 3).

Credit

Chang Liu, Hongyan Yuan, Jindie Huang, Shidian Ran, Xiaorui Wei, Xingrui Yan, Linyu Xue, Tong-Chuan He, Yuxin Zhang, Mengqin Gu, Si Wu, Fugui Zhang, Wenping Luo, Hongmei Zhang

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