Ablation of Bmp9 reduces cell proliferation and enhances intercellular junctions in HERS. (IMAGE)
Caption
(A, B) Immunofluorescent staining of Ki67 (A) and ZO-1 (B) in the mandibular first molars of wild-type (WT) littermates and Bmp9 knockout (KO) mice at 2 weeks of age (n = 6). The dashed-line boxes are enlarged. The yellow line represents HERS. (C) Quantitative analysis of Ki67 and ZO-1 expression. (D) Immunofluorescent staining of CK14 and BMP9 in the mandibular first molars of WT littermates on postnatal day 7 (PN7) and at 2 weeks (n = 6). The arrows indicate HERS. Scale bars = 50 μm.
Credit
Chang Liu, Hongyan Yuan, Jindie Huang, Shidian Ran, Xiaorui Wei, Xingrui Yan, Linyu Xue, Tong-Chuan He, Yuxin Zhang, Mengqin Gu, Si Wu, Fugui Zhang, Wenping Luo, Hongmei Zhang
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