Veratramine inhibits the growth and metastasis of osteosarcoma cells in vivo. (IMAGE)

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Veratramine inhibits the growth and metastasis of osteosarcoma cells in vivo.

Caption

(A) Schematic illustration of the in vivo anti-tumor effects of VER in BALB/c nude mice. (B) The body weight of nude mice. (C) The in vivo fluorescence images of 143B-fluc tumor-bearing mice treated with different drug groups on day 21. (D) Statistical analysis of relative fluorescence intensity. (E) The representative photo of tumors. (F) The effects of VER on tumor volume. (G) The effects of VER on tumors, lungs, heart, liver, spleen, and kidneys were detected by hematoxylin-eosin staining. (H) PCNA, Bcl-2, vimentin, MMP-2, p-PI3K, and p-AKT were detected by immunohistochemistry. Statistical significance is indicated by *P < 0.05 and **P < 0.01 versus the control group.

Credit

Zhou Xie, Xiao Qu, Ziyun Li, Yingtao Duan, Yafei Zhu, Jiayu Wang, Xueqian Han, Jun Zhang, Jinyong Luo, Xiaoji Luo

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