Analysis of the mechanism of veratramine on osteosarcoma based on network pharmacology. (IMAGE)
Caption
(A) The chemical structure of VER. (B) Venn diagram of the target of VER and the target of OS. (C) Compound-target network of VER. Pink represents VER, blue represents 82 common targets, and orange represents OS. (D) The protein interaction network diagram. The size, color, and depth changes of nodes represent the size of the degree value. The core targets were ranked based on protein-protein interaction analysis. (E, F) Two clusters based on cluster analysis using the MCODE plug-in. (G, H) Venn diagram of four algorithms employed to screen seven core candidate targets (G) and protein-protein interaction network of the seven core candidate targets (H). (I–K) Top 10 biological process (BP) terms, cellular component (CC) terms, and molecular function (MF) terms of GO enrichment analysis. (L) The bar plot of the top 10 pathways based on KEGG enrichment analysis. (M) The "drug-target-pathway-disease" network diagram.
Credit
Zhou Xie, Xiao Qu, Ziyun Li, Yingtao Duan, Yafei Zhu, Jiayu Wang, Xueqian Han, Jun Zhang, Jinyong Luo, Xiaoji Luo
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