The role of m⁶A methylation in different female reproductive diseases. (IMAGE)

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The role of m⁶A methylation in different female reproductive diseases.

Caption

m⁶A modification plays a key role in multiple female reproductive diseases, such as endometriosis (METTL3, FTO, YTHDF2, IGF2BP2), polycystic ovary syndrome (FTO, METTL3), and recurrent spontaneous abortion (METTL3, METTL14, ALKBH5). METTL3/14, methyltransferase 3/14; ALKBH5, ALKB homologue 5; FTO, fat mass and obesity-associated protein; YTHDC2, YTH domain containing 2; IGF2BP2, insulin-like growth factor-2 mRNA-binding protein 2; YTHDF2, YTH domain family 2.

Credit

Jie Ding, Yalun He, Yangshuo Li, Shuai Sun, Wen Cheng, Jiami Huang, Chaoqin Yu

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CC BY-NC-ND

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