m⁶A and body physiological state. (IMAGE)

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m⁶A and body physiological state.

Caption

Pregnancy requires the support of a healthy physiological state, and dysregulation of m⁶A methylation can lead to abnormalities in the body's condition, including depression (FTO), Hashimoto's thyroiditis (hnRNPC), diabetes (METTL3, YTHDC1), obesity (FTO, YTHDF2, METTL3, IGF2BP2), thereby affecting conception. METTL3, methyltransferase 3; FTO, fat mass and obesity-associated protein; YTHDC1/2, YTH domain containing 1/2; hnRNPC, heterogeneous nuclear ribonucleoprotein C; IGF2BP2, insulin-like growth factor-2 mRNA-binding protein 2; YTHDF2, YTH domain family 2.

Credit

Jie Ding, Yalun He, Yangshuo Li, Shuai Sun, Wen Cheng, Jiami Huang, Chaoqin Yu

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Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.

License

CC BY-NC-ND

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