CHD1 condensability is essential for gene regulation and tumor suppression (IMAGE)

Nano Life Science Institute (NanoLSI), Kanazawa University

CHD1 condensability is essential for gene regulation and tumor suppression — Caption

CHD1’s ability to form condensates is required for its localization to gene promoters (A). In prostate cancer cells carrying the CHD1 E1321fs mutation lacking the C-terminal IDR, tumors grew in nude mice, whereas restoring the deleted region suppressed tumor growth (B) and oncogene expression (C).

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Modified from Tsukamoto et al., Nature Communications (2025), CC BY 4.0.

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